Amoxicillin Alone Versus Amoxicillin/Clavulanate for Community-acquired Pneumonia in Patients Aged 65 Years or Older, and Hospitalized in a Non-intensive Care Unit Ward

Inclusion Criteria:

1. Patient aged 65 years or older with or without comorbidities defined by chronicdiseases in immunocompetent patients,

2. Patient admitted to the hospital for a CAP defined by at least two clinical signs ofpneumonia (cough, sputum production, dyspnea, tachypnea, or pleuritic pain, abnormallung auscultatory sounds, fever (temperature > 38°C) or hypothermia (<36°C)), andhad radiological evidence of a new infiltrate confirming pneumonia

3. Patient understanding oral and written French

4. Written informed consent obtained from patient prior to participation in the study (if the patient is unable to express in writing: consent by a trusted person).

5. Patients should be able to call and to answer to a phone call or to be with arelative who can help him to call or to answer questions notably raised by a medicalstaff belonging to the investigational site

Exclusion Criteria:

1. Signs of severe CAP (abscess, massive pleural effusion, serious chronic respiratoryinsufficiency, ICU admission)

2. Patient requiring ICU admission,

3. Estimated Glomerular Filtration Rate < 30 ml/min,

4. Known immunosuppression (asplenia, neutropenia, agammaglobulinemia, transplant,myeloma, lymphoma, known HIV and CD4<200/mm3),

5. Exacerbation of chronic obstructive pulmonary disease,

6. Life-threatening state expected to lead to possible imminent death,

7. Suspected atypical bacteria requiring combined antibiotics therapy,

8. Legionella suspected,

9. Subjects with clinical or epidemiological environment leading to suspect ahealthcare associated pneumonia with antibiotic resistant pathogen (includinglong-term care facility)

10. Patient known to be colonized with Pseudomonas aeruginosa or Enterobacteriaceae inthe respiratory tract,

11. Suspicion of aspiration pneumonia,

12. Administration of any antibiotic treatment for more than 24 hours before inclusion,

13. History of jaundice/hepatic impairment associated with amoxicillin/clavulanate acid,

14. History of bacterial pneumonia less than 1 month prior to study inclusion

15. History of hypersensitivity or allergy to beta-lactam or to any excipients includedin study antibiotics,

16. Subject without health insurance,

17. Subject without home address or difficulty in terms of follow-up (vacation, jobtransfer, geographical distance, lack of motivation),

18. Patient under judicial protection,

19. Diagnosis confirmed of SAR-Cov2 infection (PCR Test, covid antigen rapid test, chestcomputed tomography (CT) scan),

20. Participation to another interventional study and having an exclusion period that isstill in force during the screening phase or expected participation to anotherinterventional study during participation to the CAPTAIN study