Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic

Inclusion Criteria:

• Persons 18-60 year old with post-burn hypertrophic scars of any size which required grafting or epidermal autografting for an acute burn injury, with continued complaint of pruritus due to inadequate relief from standard of care (medical management by antihistamine and neuroleptic medications) after at least four weeks and are a minimum of four weeks after their last grafting surgery, and who speak English sufficient to participate in the study.

Exclusion Criteria:

• Currently taking Dupixent for any other diagnosis

• known allergy to Dupixent

• pregnant and or lactating mothers

• anyone treated for pruritus using laser therapy

• currently receiving adequate relief for pruritis under standard of care medicalmanagement by antihistamine or neuroleptic medications

• Currently taking steroids

• persons with developmental delays or otherwise unable to complete measures

• prisoners or anyone otherwise unable to give their own consent or who is not theirown guardian

• one or more of the following existing disorders: conjunctivitis; any co-existingdermatological condition except burns; any type of cancer; requiring dialysis;chronic Stage 3 or higher kidney disease; biliary disorder; gall bladder disorder;or another renal or hepatic disorder which, in the opinion of study physician, deemsthis study inappropriate for an eligible individual.

• Persons unable to provide their own consent, including prisoners when theirincarcerated status is not itself the focus of study, are routinely excluded fromclinical trials at this site

• We further exclude persons with other dermatological conditions (other than burn) ,which may have pruritis or pain associated with them and who may be treated withmedications other than Dupixent, and whose perceived benefit could confound ourresults.

• We similarly exclude anyone treated for pruritis by laser therapy as their perceivedbenefit could confound our results.