Multi-omics Study for Early Detection of Colorectal Cancer (MOED-CRC)

Last updated: January 28, 2024
Sponsor: Zhejiang University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Colorectal Cancer

Colon Polyps

Colon Cancer

Treatment

N/A

Clinical Study ID

NCT06220617
MOED-CRC
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The primary objective of the study is to screen multi-omics markers in blood samples and construct a prediction model for CRC based on liquid biopsy, and we will further optimize the prediction model by validating its clinical performance externally.

Eligibility Criteria

Inclusion

Inclusion Criteria for Case Arm:

  1. Aged over 18 years.
  2. Participants confirmed with colorectal adenocarcinoma or advanced adenoma throughcolonoscopy and pathological examination.
  3. Provision of informed consent prior to any study specific procedures, sampling, andanalyses. Inclusion Criteria for Control Arm:
  4. Individuals of "General risk arm" should meet all the following criteria:
  5. No history of colorectal adenomas or sessile serrated polyps.
  6. No history of inflammatory bowel disease (8-10 years ).
  7. No family history (first-degree relatives) of colorectal cancer.
  8. Individuals of "High-risk arm" should meet at least one of the following criteria:
  9. Asia-Pacific Colorectal Screening (APC) score ≥ 3.
  10. Family history (first-degree relatives) of colorectal cancer.
  11. History of positive fecal occult blood test.
  12. Any 2 of the following: chronic diarrhea, chronic constipation, mucous bloodystools, history of psychological stimulation, history of chronic appendicitis orappendectomy, history of chronic biliary disease or cholecystectomy.
  13. Individuals with inflammatory bowel disease.
  14. All participants must be confirmed not to have colorectal malignancy or advancedadenomas through colonoscopy.
  15. Provision of informed consent prior to any study specific procedures, sampling, andanalyses.

Exclusion

Exclusion Criteria:

  1. History of other malignant tumors (excluding non-melanoma skin cancer).
  2. Prior or related treatments previously (including colorectal cancer or advancedadenoma surgery, endoscopic treatment, chemotherapy, targeted therapy, immunotherapy,radiation, neoadjuvant therapy, etc.).
  3. Patients with hereditary colorectal diseases (including Lynch syndrome, familial CRCtype X (FCCX), familial adenomatous polyposis (FAP), MUTHY-associated polyposis (MAP),Peutz-Jeghers syndrome (PJS), juvenile polyposis syndrome (JPS), serrated polyposissyndrome (SPS), etc.).
  4. Usage of anti-tumor drugs such as methotrexate, cyclophosphamide, mercaptopurine, andbendamustine for other diseases within 30 days before blood collection.
  5. Prior blood transfusion (including blood components) within the past 2 weeks.
  6. Prior organ transplantation, bone marrow transplantation, or stem celltransplantation.
  7. Pregnancy women.
  8. Prior or current anti-infection treatment within 14 days before blood collection.
  9. Inability to comply with study procedures such as blood collection and relatedexaminations.
  10. Deemed unsuitable for participation in the clinical trial by the investigator.

Study Design

Total Participants: 3600
Study Start date:
January 11, 2024
Estimated Completion Date:
June 30, 2027

Study Description

This multicenter research intends to enroll 3,600 participants according to predefined inclusion and exclusion criteria. The study will be divided into two groups: the "cancer arm" and the "control arm", with the "control arm" further subdivided into the "general-risk arm" and the "high-risk arm". All participants enrolled in this study will be required to provide a 10 ml whole blood sample.

This study consists of two sections. The first section involves constructing an diagnostic prediction model for early CRC detection, and the second section focuses on validating and optimizing this prediction model.

In the first section, a prediction model for the early detection of CRC will be developed with a cohort of 1,700 participants. This cohort comprises 900 individuals in the cancer arm, including 800 CRC patients and 100 with advanced adenoma (AA), along with 800 individuals in the control rm. All participants will be required to provide a 10 ml blood sample. Cell-free DNA (cfDNA) and microRNA (miRNA) will be sequenced and analyzed with the next-generation sequencing (NGS) platform,. And cancer specific markers will be identified to construct an early detection liquid biopsy prediction model by leveraging machine learning techniques and incorporating clinical pathological diagnostic information.

In the second section, a total of 1,900 participants were include, with 1,100 in the "cancer arm" (800 CRC and 300 AA patients) and 800 in the "control arm", the prediction model established in the first section will be validated in an external cohort, and algorithm optimization will be performed.

Connect with a study center

  • The Second Affiliated Hospital of Zhejiang University

    Hangzhou, Zhejiang 31000
    China

    Active - Recruiting

  • Sun Yat-Sen University Cancer Hospital

    Guangzhou,
    China

    Active - Recruiting

  • Yunnan cancer hospital

    Kunming,
    China

    Active - Recruiting

  • Jiangsu province hospital

    Nanjing,
    China

    Active - Recruiting

  • The first affiliated hospital of Xi'an Jiaotong University

    Xi'an,
    China

    Active - Recruiting

  • Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou University

    Zhengzhou,
    China

    Active - Recruiting

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