Mitoxantrone Hydrochloride Liposome Injection-containing Bridging Regimen and CD19-targeting CAR-T Therapies

Inclusion Criteria:

1. Aged ≥ 18 years and <75 years.
2. Eastern Cooperative Oncology Group score≤ 2.
3. Clinically diagnosed refractory or relapsed B-cell malignancies. Relapse refers to "relapse after a complete response (CR) from initial chemotherapy"; refractory refersto "diagnosis can be made if any of the following are met:(1) tumor shrinkage of <50%or disease progression (PD) after standard chemotherapy; (2) CR is achieved bystandard chemotherapy but relapses within six months, (3) 2 or more recurrences afterCR, (4) recurrence after hematopoietic stem cell transplantation"; B-cell malignanciesinclude the following 3 categories: (1) B-cell acute lymphoblastic leukemia (B-ALL); (2) indolent B-cell lymphoma (CLL, FL, MZL); (3) aggressive B-cell lymphoma (DLBCL,BL, MCL).
4. Flow cytometry (FCM) or immunohistochemistry showed positive CD19 expression in tumorcells;
5. Organ function needs to meet the following conditions:

1. EF >50%, and there is no obvious abnormality on ECG; 2) SpO2≥90%； 3) Cr≤2.5 ULN; 4) ALTand AST≤5 ULN, TBil≤3 ULN; 6. Negativity of blood pregnancy test for women, andparticipants use effective methods of contraception until the last follow-up. 7. Thepatient or his or her legal guardian voluntarily participates in and signs an informedconsent form.

Exclusion Criteria:

1. Prior treatment with doxorubicin or other anthracyclines with a total cumulative doseof doxorubicin >360 mg/m2 (other anthracyclines convert 1 mg of doxorubicin to 2 mgepirubicin).
2. Hypersensitivity to any of the study drugs or their components.
3. Concomitant other diseases that are not effectively controlled, including but notlimited to persistent or poorly controlled infections, symptomatic congestive heartfailure, unstable angina, cardiac arrhythmias, poorly controlled pulmonary diseases,or psychiatric disorders.
4. Investigators judge patients with central nervous system involvement who may be athigh risk of receiving bridging therapy and CD19 CAR-T cell treatment.
5. Participants with other active malignancies within five years.
6. Patients with relapse after allogeneic hematopoietic stem cell transplantation whohave had grade 3~4 acute graft-versus-host response (GVHD).
7. Patients who are pregnant or breast-feeding.
8. Active autoimmune disease requiring systemic immunosuppressive therapy.
9. Other conditions considered to increase the risk to the subject or interfere with theresults of the trial by the researcher.