Adaptive Radiotherapy in Head and Neck Tumor Patients

Last updated: September 25, 2024
Sponsor: University Hospital, Essen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Nasopharyngeal Cancer

Human Papilloma Virus (Hpv)

Head And Neck Cancer

Treatment

image guided radiotherapy without online adaptation

Adaptive Radiotherapy

Clinical Study ID

NCT06216171
23-11674-BO
  • Ages > 18
  • All Genders

Study Summary

Most newly diagnosed oropharyngeal and hypopharyngeal cancers are treated with radiochemotherapy with curative intent. If the field-set UP margins are broad, the consequence may be that quality of life is impaired. The study group of Nutting et al. (2023) investigated this year whether dysphagia-optimized intensity-modulated radiotherapy can reduce the radiation dose to structures associated with dysphagia and aspiration and improve swallowing function compared to standard IMRT (Nutting C, Finneran L, Roe J, Petkar I, Rooney K, Hall E; DARS Triallist Group. Dysphagia-optimized intensity-modulated radiotherapy versus standard radiotherapy in patients with pharyngeal cancer - Authors' reply. Lancet Oncol. 2023 Oct;24(10):e398. doi: 10.1016/S1470-2045(23)00457-6. PMID: 37797636.) The study group concluded that the results suggest that dysphagia-optimized IMRT improves patient-reported swallowing function compared to standard IMRT. DO-IMRT should be considered the new standard of care for patients receiving radiotherapy for pharyngeal cancer, and ART could further improve outcomes.

Eligibility Criteria

Inclusion

Inclusion Criteria:

ECOG 0/1 No prior cancer treatment

Exclusion

Exclusion Criteria:

ECOG 2-4 Prior cancer treatment

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: image guided radiotherapy without online adaptation
Phase:
Study Start date:
January 25, 2024
Estimated Completion Date:
January 30, 2028

Study Description

Most newly diagnosed oropharyngeal and hypopharyngeal cancers are treated with radiochemotherapy with curative intent. If the field-set UP margins are broad, the consequence may be that quality of life is impaired. The study group of Nutting et al. (2023) investigated this year whether dysphagia-optimized intensity-modulated radiotherapy can reduce the radiation dose to structures associated with dysphagia and aspiration and improve swallowing function compared to standard IMRT (Nutting C, Finneran L, Roe J, Petkar I, Rooney K, Hall E; DARS Triallist Group. Dysphagia-optimized intensity-modulated radiotherapy versus standard radiotherapy in patients with pharyngeal cancer - Authors' reply. Lancet Oncol. 2023 Oct;24(10):e398. doi: 10.1016/S1470-2045(23)00457-6. PMID: 37797636.) The study group concluded that the results suggest that dysphagia-optimized IMRT improves patient-reported swallowing function compared to standard IMRT. DO-IMRT should be considered the new standard of care for patients receiving radiotherapy for pharyngeal cancer, and ART could further improve outcomes.

Thus, in this trial we analyze ART in head and neck cancer in a prospective randomized trial.

Connect with a study center

  • Maja Guberina

    Essen, 45147
    Germany

    Active - Recruiting

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