A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa

Last updated: May 2, 2025
Sponsor: Incyte Corporation
Overall Status: Active - Recruiting

Phase

3

Condition

Scalp Disorders

Rosacea

Acne Inversa

Treatment

Povorcitinib

Clinical Study ID

NCT06212999
INCB 54707-312
2023-507204-31-00
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to evaluate long-term safety and efficacy of povorcitinib in participants with moderate to severe hidradenitis suppurativa who completed the 54 weeks of study treatment within the originating parent Phase 3 studies (INCB 54707-301 [NCT05620823] or INCB 54707-302 [NCT05620836]).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Completion of the study treatment period of the originating parent study (INCB 54707-301 or INCB 54707-302).

  • Agreement to use contraception.

  • Willing and able to comply with the study protocol and procedures.

  • Further inclusion criteria apply.

Exclusion

Exclusion Criteria:

  • Participation in the extension study could expose the participant to an undue safetyrisk.

  • Women who are pregnant (or who are considering pregnancy) or breastfeeding.

  • Further exclusion criteria apply.

Study Design

Total Participants: 960
Treatment Group(s): 1
Primary Treatment: Povorcitinib
Phase: 3
Study Start date:
January 30, 2024
Estimated Completion Date:
December 26, 2026

Connect with a study center

  • Investigative Site AU205

    Kogarah, New South Wales 02217
    Australia

    Active - Recruiting

  • Investigative Site AU203

    Kotara, New South Wales 02289
    Australia

    Active - Recruiting

  • Investigative Site AU200

    Liverpool, New South Wales 02170
    Australia

    Active - Recruiting

  • Investigator Site AU200

    Liverpool, New South Wales 02170
    Australia

    Active - Recruiting

  • Investigative Site AU202

    Benowa, Queensland 04217
    Australia

    Site Not Available

  • Investigative Site AU206

    Woolloongabba, Queensland 04102
    Australia

    Active - Recruiting

  • Investigative Site AU207

    Woolloongabba, Queensland 04102
    Australia

    Site Not Available

  • Investigative Site AU201

    Carlton, Victoria 03053
    Australia

    Site Not Available

  • Investigator Site AU201

    Carlton, Victoria 03053
    Australia

    Site Not Available

  • Investigative Site AU204

    Melbourne, Victoria 03002
    Australia

    Active - Recruiting

  • Investigator Site AU204

    Melbourne, Victoria 03002
    Australia

    Active - Recruiting

  • Investigative Site AT304

    Graz, 08036
    Austria

    Site Not Available

  • Investigative Site AT306

    Innsbruck, 06020
    Austria

    Site Not Available

  • Investigative Site AT306

    Inssbruck, 06020
    Austria

    Active - Recruiting

  • Investigative Site AT302

    Linz, 04020
    Austria

    Site Not Available

  • Investigative Site AT303

    Vienna, 01030
    Austria

    Site Not Available

  • Investigative Site AT305

    Vienna, 01090
    Austria

    Active - Recruiting

  • Investigator Site AT303

    Vienna, 01030
    Austria

    Site Not Available

  • Investigative Site AT300

    Wien, 01130
    Austria

    Site Not Available

  • Investigative Site AT301

    Wien, 01100
    Austria

    Site Not Available

  • Investigative Site AT305

    Wien, 01090
    Austria

    Site Not Available

  • Investigative Site BE300

    Brussels, 01070
    Belgium

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  • Investigative Site BE304

    Brussels, 01200
    Belgium

    Site Not Available

  • Investigative Site BE301

    Gent, 09000
    Belgium

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  • Investigative Site BE306

    Gent, 09000
    Belgium

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  • Investigative Site BE301

    Ghent, 09000
    Belgium

    Active - Recruiting

  • Investigative Site BE305

    Leuven, 03000
    Belgium

    Site Not Available

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    Liege, 04000
    Belgium

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  • Investigative Site BE303

    Namur, 05000
    Belgium

    Site Not Available

  • Investigative Site BG200

    Sofia, 01510
    Bulgaria

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    Sofia, 01463
    Bulgaria

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  • Investigative Site BG203

    Sofia, 01407
    Bulgaria

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  • Investigative Site BG204

    Sofia, 01606
    Bulgaria

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  • Investigator Site BG204

    Sofia, 01606
    Bulgaria

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    Stara Zagora, 06000
    Bulgaria

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  • Investigative Site CA202

    Calgary, Alberta T3E 0B2
    Canada

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  • Investigative Site CA204

    Edmonton, Alberta T6G 1C3
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  • Investigative Site CA200

    Surrey, British Columbia V3V 0C6
    Canada

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  • Investigative Site CA301

    Winnipeg, Manitoba R3M 3Z4
    Canada

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  • Investigative Site CA205

    Fredericton, New Brunswick E3B 1G9
    Canada

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  • Investigative Site CA304

    Barrie, Ontario L4M 7G1
    Canada

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    Barrie, Ontario L4M 1G7
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    Hamilton, Ontario L8L 3C3
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    Hamilton, Ontario L8V 1C3
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    London, Ontario N6H 5L5
    Canada

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  • Investigative Site CA207

    Mississauga, Ontario L4W 0C2
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    Peterborough, Ontario K9J 5K2
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    Richmond Hill, Ontario L4B 1L1
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    Richmond Hill, Ontario L4B 1L1
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    Laval, Quebec H7N 6L2
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    Montreal, Quebec H2X 2V1
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    St-jérôme, Quebec J7Z 7E2
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    St-jérôme, Quebec J7Z 7E2
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    St. John's, A1A 4Y3
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    Ostrava - Poruba, 708 52
    Czechia

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    Ostrava - Poruba, 708 52
    Czechia

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  • Investigative Site CZ300

    Praha 5, 150 06
    Czechia

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    Aarhus, 08000
    Denmark

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    Roskilde, 04000
    Denmark

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    Antony, 92160
    France

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    Bordeaux, 33000
    France

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    Brest Cedex 2, 29609
    France

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    Brest Cedex 2, 29609
    France

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    Dijon, 21000
    France

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    Dijon, 21000
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    Le Mans Cedex, 72037
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    Le Mans Cedex 9, 72037
    France

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    Lyon, 69003
    France

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    Lyon, 69003
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    Lyon Cedex 03, 69437
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    Marseille Cedex 5, 13385
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    Marseille Cedex 5, 13385
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    Nantes, 44093
    France

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    Nantes, 44093
    France

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    Nice Cedex 3, 06200
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    Paris, 75010
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    Paris, 75010
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    Reims, 51100
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    Reims, 51100
    France

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    Rouen, 76031
    France

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    Rouen Cedex, 76031
    France

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  • Investigative Site FR301

    Saint Etienne Cedex 2, 42055
    France

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  • Investigative Site FR301

    Saint Priest En Jarez, 42270
    France

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    Saint-priest-en-jarez, 42270
    France

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  • Investigative Site FR201

    Toulon, 83000
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  • Investigative Site FR306

    Toulouse, 31059
    France

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  • Investigative Site FR306

    Toulouse Cedex 9, 31059
    France

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  • Investigator Site FR306

    Toulouse Cedex 9, 31059
    France

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  • Investigative Site DE202

    Berlin, 10117
    Germany

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  • Investigative Site DE203

    Bochum, 44791
    Germany

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  • Investigative Site DE305

    Darmstadt, 64283
    Germany

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  • Investigative Site DE201

    Dessau, 06847
    Germany

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  • Investigative Site DE201

    Dessau-rosslau, 06847
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  • Investigative Site DE302

    Dresden, 01307
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  • Investigator Site DE302

    Dresden, 01307
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  • Investigative Site DE306

    Duesseldorf, 40225
    Germany

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  • Investigative Site DE207

    Erlangen, 91054
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  • Investigative Site DE301

    Frankfurt, 60590
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    Frankfurt, 60590
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  • Investigative Site DE208

    Goettingen, 37075
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    Gottingen, 37075
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  • Investigative Site DE303

    Hamburg, 20246
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    Hannover, 30159
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    Heidelberg, 69120
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  • Investigative Site DE200

    Kiel, 24105
    Germany

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  • Investigative Site DE304

    Langenau, 89129
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  • Investigative Site DE205

    Leipzig, 04103
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  • Investigative Site DE204

    Lubeck, 23562
    Germany

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  • Investigative Site DE307

    Memmingen, 87700
    Germany

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  • Investigator Site DE307

    Memmingen, 87700
    Germany

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  • Investigative Site DE206

    Merzig, 66663
    Germany

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  • Investigative Site GR300

    Athens, 12462
    Greece

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  • Investigative Site GR303

    Athens, 16121
    Greece

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  • Investigator Site GR303

    Athens, 16121
    Greece

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  • Investigative Site GR301

    Thessaloniki, 54643
    Greece

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  • Investigative Site GR302

    Thessaloniki, 56403
    Greece

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  • Investigative Site IT200

    Ancona, 60126
    Italy

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  • Investigator Site IT200

    Ancona, 60126
    Italy

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  • Investigative Site IT204

    Brescia, 25123
    Italy

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  • Investigative Site IT207

    Catania, 95123
    Italy

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  • Investigator Site IT207

    Catania, 95123
    Italy

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  • Investigative Site IT202

    Milano, 20122
    Italy

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  • Investigator Site IT202

    Milano, 20122
    Italy

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  • Investigative Site IT203

    Napoli, 80131
    Italy

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  • Investigator Site IT203

    Napoli, 80131
    Italy

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  • Investigative Site IT206

    Pisa, 56126
    Italy

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  • Investigator Site IT206

    Pisa, 56126
    Italy

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  • Investigative Site IT205

    Roma, 00136
    Italy

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  • Investigative Site IT205

    Rome, 00137
    Italy

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  • Investigative Site IT201

    Rozzano, 20089
    Italy

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  • Investigator Site IT201

    Rozzano, 20089
    Italy

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  • Investigative Site IT200

    Torrette, 60126
    Italy

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  • Investigative Site JP301

    Ginowan-shi, 901-2725
    Japan

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  • Investigator Site JP301

    Ginowan-shi, 901-2725
    Japan

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  • Investigative Site JP306

    Ibaraki, 305-8576
    Japan

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  • Investigative Site JP304

    Itabashi-ku, 173-8610
    Japan

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  • Investigative Site JP305

    Kurume, 830-0011
    Japan

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  • Investigative Site JP300

    Kyoto, 602-8566
    Japan

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  • Investigative Site JP300

    Kyoto-shi, 602-8566
    Japan

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  • Investigative Site JP301

    Nakagami-gun, 903-0215
    Japan

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    Niigata-shi, 951-8520
    Japan

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  • Investigative Site JP307

    Nishinomiya-shi, 663-8186
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    Sapporo-shi, 060-8648
    Japan

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  • Investigative Site JP302

    Sendai-shi, 980-8574
    Japan

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  • Investigator Site JP302

    Sendai-shi, 980-8574
    Japan

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  • Investigative Site JP309

    Shinjuku-ku, 160-0023
    Japan

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  • Investigative Site JP309

    Tokyo, 160-0023
    Japan

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  • Investigative Site NL302

    Breda, 4818 CK
    Netherlands

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  • Investigator Site NL302

    Breda, 4818 CK
    Netherlands

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  • Investigative Site NL303

    Groningen, 9713 GZ
    Netherlands

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  • Investigator Site NL303

    Groningen, 9713 GZ
    Netherlands

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  • Investigative Site NL301

    Rotterdam, 3015 GD
    Netherlands

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  • Investigative Site PL203

    Lublin, 20573
    Poland

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  • Investigative Site PL304

    Ostrowiec, 27-400
    Poland

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  • Investigative Site PL304

    Ostrowiec Swietokrzyski, 27-400
    Poland

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  • Investigator Site PL304

    Ostrowiec Swietokrzyski, 27-400
    Poland

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    Poznan, 60-529
    Poland

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    Rzeszow, 35-055
    Poland

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    Warsaw, 02-962
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    Warszawa, 02-507
    Poland

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  • Investigative Site PL202

    Warszawa, 02-962
    Poland

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  • Investigator Site PL201

    Warszawa, 02-507
    Poland

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  • Investigative Site PL301

    Wroclaw, 50-566
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  • Investigative Site PL302

    Wroclaw, 51-503
    Poland

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  • Investigator Site PL302

    Wroclaw, 51-503
    Poland

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  • Investigative Site ES203

    Alicante, 03010
    Spain

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  • Investigator Site ES203

    Alicante, 03010
    Spain

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  • Investigative Site ES302

    Badalona, 08916
    Spain

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  • Investigator Site ES302

    Badalona, 08916
    Spain

    Active - Recruiting

  • Investigative Site ES303

    Barcelona, 08003
    Spain

    Active - Recruiting

  • Investigator Site ES303

    Barcelona, 08003
    Spain

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  • Investigative Site ES301

    Granada, 18014
    Spain

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  • Investigative Site ES202

    Las Palmas de Gran Canaria, 35010
    Spain

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  • Investigator Site ES202

    Las Palmas de Gran Canaria, 35010
    Spain

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  • Investigative Site ES201

    Madrid, 28009
    Spain

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  • Investigative Site ES204

    Madrid, 28006
    Spain

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    Madrid, 28040
    Spain

    Active - Recruiting

  • Investigative Site ES305

    Madrid, 28041
    Spain

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  • Investigator Site ES201

    Madrid, 28007
    Spain

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  • Investigator Site ES205

    Madrid, 28040
    Spain

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  • Investigator Site ES305

    Madrid, 28041
    Spain

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  • Investigative Site ES200

    Manises, 46940
    Spain

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  • Investigative Site ES300

    Pontevedra, 36001
    Spain

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  • Investigative Site ES304

    Santiago de Compostela, 15706
    Spain

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  • Investigator Site ES304

    Santiago de Compostela, 15706
    Spain

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    Valencia, 46940
    Spain

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    Birmingham, B15 2GW
    United Kingdom

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  • Investigator Site GB202

    Birmingham, B15 2GW
    United Kingdom

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  • Investigative Site GB200

    Dudley, DY1 2HQ
    United Kingdom

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    Leeds, LS7 4SA
    United Kingdom

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    London, SE1 9RT
    United Kingdom

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    Salford, M6 8HD
    United Kingdom

    Active - Recruiting

  • Investigator Site GB203

    Salford, M6 8HD
    United Kingdom

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  • Investigative Site US303

    Phoenix, Arizona 85006
    United States

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    Scottsdale, Arizona 85259
    United States

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    Scottsdale, Arizona 85255
    United States

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  • Investigator Site US240

    Scottsdale, Arizona 85255
    United States

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    Fort Smith, Arkansas 72916
    United States

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    Rogers, Arkansas 72758
    United States

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    Laguna Niguel, California 92677
    United States

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  • Investigative Site US223

    Los Angeles, California 90033
    United States

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  • Investigator Site US223

    Los Angeles, California 90033
    United States

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    Oakland, California 94611
    United States

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    San Diego, California 92103
    United States

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    San Francisco, California 94118
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    San Francisco, California 94115
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    Washington, District of Columbia 20060
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    Brandon, Florida 33511
    United States

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    Clearwater, Florida 33614
    United States

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    Hialeah, Florida 33012-3618
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    Hollywood, Florida 33021
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    Hollywood, Florida 33021
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    Maitland, Florida 32751
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    Margate, Florida 33063
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    Miami, Florida 33125
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    Miami, Florida 33173
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    North Miami Beach, Florida 33162-4708
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    Ocala, Florida 34470
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    Orlando, Florida 32819
    United States

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    Tampa, Florida 33613
    United States

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    Marietta, Georgia 30060
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    Skokie, Illinois 60077
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    West Dundee, Illinois 60118
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    West Dundee, Illinois 60118
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    Indianapolis, Indiana 46250
    United States

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  • Investigative Site US337

    Indianapolis, Indiana 46250
    United States

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    Indianapolis, Indiana 46250
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    Bowling Green, Kentucky 42104
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    Bowling Green, Kentucky 42104
    United States

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    Louisville, Kentucky 40241
    United States

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  • Investigative Site US229

    Baton Rouge, Louisiana 70809
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    Baton Rouge, Louisiana 70809
    United States

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  • Investigative Site US207

    Metairie, Louisiana 70006
    United States

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    New Orleans, Louisiana 70115
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    Baltimore, Maryland 21287
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    Marriottsville, Maryland 21104
    United States

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    Marriottsville, Maryland 21104
    United States

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    Beverly, Massachusetts 01915
    United States

    Site Not Available

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    Beverly, Massachusetts 01915
    United States

    Site Not Available

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    Boston, Massachusetts 02115
    United States

    Active - Recruiting

  • Investigative Site US304

    Boston, Massachusetts 02215
    United States

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    Brighton, Massachusetts 02135
    United States

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  • Investigative Site US310

    Needham, Massachusetts 02492
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    Quincy, Massachusetts 02169
    United States

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    Fort Gratiot, Michigan 48059
    United States

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    Waterford, Michigan 48328
    United States

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  • Investigator Site US217

    Waterford, Michigan 48328
    United States

    Active - Recruiting

  • Investigative Site US212

    Minneapolis, Minnesota 55455
    United States

    Active - Recruiting

  • Investigator Site US212

    Minneapolis, Minnesota 55455
    United States

    Site Not Available

  • Investigative Site US302

    Saint Louis, Missouri 63110
    United States

    Active - Recruiting

  • Investigative Site US239

    Omaha, Nebraska 68144
    United States

    Site Not Available

  • Investigator Site US239

    Omaha, Nebraska 68144
    United States

    Site Not Available

  • Investigative Site US318

    Portsmouth, New Hampshire 03801
    United States

    Active - Recruiting

  • Investigative Site US230

    East Windsor, New Jersey 08520
    United States

    Active - Recruiting

  • Investigative Site US324

    Forest Hills, New York 11375
    United States

    Site Not Available

  • Investigative Site US324

    Kew Gardens, New York 11415
    United States

    Active - Recruiting

  • Investigator Site US324

    Kew Gardens, New York 11415
    United States

    Active - Recruiting

  • Investigative Site US202

    New York, New York 10028
    United States

    Active - Recruiting

  • Investigative Site US210

    Rochester, New York 14642
    United States

    Site Not Available

  • Investigative Site US205

    Chapel Hill, North Carolina 27516
    United States

    Active - Recruiting

  • Investigative Site US215

    Bexley, Ohio 43209
    United States

    Active - Recruiting

  • Investigative Site US339

    Bexley, Ohio 43209
    United States

    Site Not Available

  • Investigator Site US215

    Bexley, Ohio 43209
    United States

    Active - Recruiting

  • Investigator Site US339

    Bexley, Ohio 43209
    United States

    Site Not Available

  • Investigative Site US330

    Boardman, Ohio 44512
    United States

    Site Not Available

  • Investigator Site US330

    Boardman, Ohio 44512
    United States

    Site Not Available

  • Investigative Site US314

    Cincinnati, Ohio 45219
    United States

    Active - Recruiting

  • Investigative Site US312

    Cleveland, Ohio 44106
    United States

    Active - Recruiting

  • Investigator Site US312

    Cleveland, Ohio 44106
    United States

    Active - Recruiting

  • Investigative Site US203

    Columbus, Ohio 43210
    United States

    Site Not Available

  • Investigative Site US215

    Columbus, Ohio 43209
    United States

    Site Not Available

  • Investigative Site US203

    Gahanna, Ohio 43230
    United States

    Active - Recruiting

  • Investigative Site US301

    Portland, Oregon 97201
    United States

    Active - Recruiting

  • Investigative Site US232

    Murfreesboro, Tennessee 37130
    United States

    Site Not Available

  • Investigative Site US235

    Arlington, Texas 76011
    United States

    Site Not Available

  • Investigator Site US235

    Arlington, Texas 76011
    United States

    Site Not Available

  • Investigative Site US218

    Bellaire, Texas 77401
    United States

    Active - Recruiting

  • Investigative Site US340

    Bellaire, Texas 77401
    United States

    Site Not Available

  • Investigator Site US340

    Bellaire, Texas 77401
    United States

    Site Not Available

  • Investigative Site US238

    Pflugerville, Texas 78660
    United States

    Site Not Available

  • Investigator Site US238

    Pflugerville, Texas 78660
    United States

    Site Not Available

  • Investigative Site US300

    Plano, Texas 75025
    United States

    Active - Recruiting

  • Investigative Site US234

    San Antonio, Texas 78213
    United States

    Active - Recruiting

  • Investigative Site US313

    Norfolk, Virginia 23502
    United States

    Active - Recruiting

  • Investigative Site US308

    Spokane, Washington 99202
    United States

    Active - Recruiting

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