Effect of a DASH-Style Diet on Urinary Risk Factors for Kidney Stone Disease

Phase

N/A

Condition

Kidney Stones

Treatment

DASH-Style Diet

Western-Style Diet

Clinical Study ID

NCT06210009

IRB-300012217

Ages 19-89
All Genders

Study Summary

The true capacity for a healthy diet to improve urinary stone risk factors is not well-defined. The objective of this study is to measure the effect of adopting a healthy dietary pattern on kidney stone disease (KSD) risk. The working hypothesis is that a Dietary Approaches to Stop Hypertension (DASH)-style diet will improve 24-hour urine stone risk parameters. The approach to testing this hypothesis will be to randomize participants with KSD to a standardized DASH-style vs. Western-style diet for one week. The Bionutrition Unit of the Center for Clinical and Translational Science will provide all meals to participants. The rationale for this study is that by measuring the effect of a DASH-style diet on urinary stone risk parameters, a benchmark for future real-world, implementation studies will be established. Based on available evidence, this will be the first controlled diet study to assess the DASH dietary pattern for improving urinary stone risk parameters.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Birmingham, AL area participants of the Coronary Artery Risk Development in YoungAdults (CARDIA) study OR patients of the University of Alabama at Birmingham/KirklinClinic
Self-reported, documented, and/or prior imaging-based diagnosis of kidney stonedisease
Age 19-89
Any sex
Any race
Able to provide informed consent
Willing to perform 24-hour urine collections
Willing to consume meals prepared by Bionutrition Unit
No food allergies/intolerance to any of the foods in the study menus
Willing to stop for 7 days before and during study: Multivitamins and/or Dietarysupplements (including calcium and vitamin C)

Exclusion

Exclusion Criteria:

Dialysis
Kidney transplant recipient
Estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m2 based on historicallaboratory measurements
Renal tubular acidosis
Current use of acetazolamide, topiramate, or zonisamide
Primary hyperparathyroidism or history of parathyroidectomy
Hyperthyroidism
Sarcoidosis
Primary hyperoxaluria
Cystinuria
Nephrotic syndrome
Malabsorptive conditions including inflammatory bowel disease or history ofmalabsorptive surgery (e.g., Roux-en-Y gastric bypass, small bowel resection)
Urinary retention requiring catheterization
Urinary diversion
Pregnancy
Breastfeeding
Malignancy treated in the past 12 months other than non-melanoma skin cancer

Study Design