The Involvement of the Gut Hormone GIP in the Pathophysiology of Post Prandial Hypotension

Inclusion Criteria:

1. Age 18-85 years

2. History of PPH-related symptoms like dizziness, lightheadedness, palpitations, orfainting after meal ingestion

3. Informed consent

Exclusion Criteria:

1. Not fulfilling the PPH diagnosis during the mixed meal test or during the test mealwith increased (+25%) number of calories

2. Treatment with antihypertensives

3. Treatment with SNRI (Serotonin and Noradrenalin Reuptake Inhibitor) or treatmentwithin three months before screening visit

4. Allergy or intolerance to ingredients included in the mixed meal

5. Any ongoing medication that the investigator evaluates would interfere with trialparticipation

6. Any physical or psychological condition that the investigator evaluates wouldinterfere with trial participation, including any acute or chronic illnesses

7. Anaemia (haemoglobin below normal range <7.3 mmol/L for women and <8.3 mmol/L formen)

8. Moderate to severe loss of kidney function (estimated glomerular filtration rate (eGFR) <45 ml/min/1.73 m2) at screening

9. Known liver disease (except for simple steatosis) and/or elevated plasma alanineaminotransferase (ALT) > three times the upper limit of normal at screening

10. Any concomitant disease or treatment that, at the discretion of the investigators,might jeopardize the participant's safety during the trial

11. Alcohol/drug abuse as per discretion of the investigators

12. Pregnancy or breastfeeding

13. Participation in any other clinical trial during study period

14. Mental incapacity or language barriers that preclude adequate understanding orcooperation or unwillingness to comply with trial requirements or pr discretion ofthe investigator