Diaphragm Structure and Function in Childhood Cancer Survivors

Last updated: December 3, 2024
Sponsor: University of Maryland, Baltimore
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neuroblastoma

Cancer (Pediatric)

Retinoblastoma

Treatment

POWERbreathe Plus IMT

Clinical Study ID

NCT06205251
HP-00106329
  • Ages 6-12
  • All Genders

Study Summary

The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in childhood cancer survivors.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Completed medical treatment (chemotherapy, chemotherapy/surgery,chemotherapy/radiation or any combination of cancer treatment) for any type ofcancer, except for cancer of the central nervous system, at least 1 year ago

Exclusion

Exclusion Criteria:

  • History of neuromuscular, cardiac, or pulmonary disease prior to the diagnosis ofcancer

  • Recent injury or condition (less than 6 months ago) that precludes strength testingor walking

  • Dyspnea with minimal activity (4 on the modified Medical Research Council DyspneaScale)

Study Design

Total Participants: 13
Treatment Group(s): 1
Primary Treatment: POWERbreathe Plus IMT
Phase:
Study Start date:
March 15, 2024
Estimated Completion Date:
April 30, 2025

Study Description

During the first study visit, participants will undergo a series of pulmonary function and muscle performance tests followed by treadmill walking trials at different speeds with concurrent expired gas analysis via a face mask. The participants will then perform a training program for the breathing muscles at home for 6 weeks. The research team will follow up each week via telehealth visits to support training. After the 6-week training program, participants will return in-person for a follow-up visit and will undergo the same series of assessments as the first visit.

Connect with a study center

  • University of Maryland, Baltimore

    Baltimore, Maryland 21201
    United States

    Active - Recruiting

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