Evaluation of the Diaphragm Performance During Weaning From Mechanical Ventilation

Last updated: January 11, 2024
Sponsor: Mongi Slim Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

diaphragm ultrasound monitoring

Clinical Study ID

NCT06203353
Diaphram Tissue Doppler
  • Ages > 18
  • All Genders

Study Summary

Prospective observationnal study, including ICU adult patients with invasive mechanical ventilation for at least 48 hours. Patients are included when performing weaning from mechanical ventilation with pressure support (lowest level of pressure support).

Before separating the patient from the ventilator and performing a T tube spontaneous breathing test, diaphragm ultrasound is performed bilaterally : diaphragm excursion, diaphragm thickening fraction and maximal contraction and relaxation velocities with tissue doppler imaging.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Invasive mechanical ventilation for at least 48 hours

Exclusion

Exclusion Criteria:

  • reintubation for extra respiratory failure (neurologic or hemodynamic)
  • Patients with chronic repiratory failure

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: diaphragm ultrasound monitoring
Phase:
Study Start date:
November 01, 2023
Estimated Completion Date:
December 30, 2024

Study Description

This observationnal study will include patients during weaning from invasive mechanical ventilation: ventilation in pressure support with the lowest level With normal neurological status: glasgow coma scale > 13 Requiring no vasopressor support

conventionnal diaphragm parameters: diaphram excursion and thickening fraction will be collected bilaterally with the tissue doppler measures: maximal contraction and relaxation velocities, immediately before a T Tube test.

Patients will be divided into 2 groups according to their weaning from mechanicla ventilation outcome, and diaphragm ultrasound patterns will be compared between the 2 groups in order to evaluate the performance of tissue doppler in predicting weaning outcome.

Connect with a study center

  • Mongi Slim hospital

    Tunis, 2085
    Tunisia

    Active - Recruiting

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