NYSCF Scientific Discovery Biobank

Inclusion Criteria:

• Age 30 days or older.

• Diagnosis and/or medical history of a condition, disease, genetic background, ortrait of interest or healthy control.

• Adults with decisional capacity must provide written informed consent unlessphysical limitations preclude signing.

• Adults without decisional capacity to consent must a have diagnosis of AmyotrophicLateral Sclerosis (ALS), Alzheimer's Disease and Related Dementias (AD/ADRD); BattenDisease, Corticobasal Degeneration (CBD), Dementia, Frontotemporal Dementia (FTD),Huntington Disease, Lewy Body Disease, Multiple Sclerosis, Multiple System Atrophy,Parkinson's Disease (PD), Parkinsonism, and/or Progressive Supranuclear Palsy, andmust provide assent; a legally authorized representative (LAR) must also providewritten informed consent.

• Minors undergoing skin collection for research purposes must have a condition,disease, genetic background, or trait of interest and parental/guardian consent.

• Minors undergoing blood, and/or saliva collection for research purposes may have acondition, disease, genetic background, or trait of interest or serve as a healthycontrol and must have an available parent/guardian to provide consent.

• Minors transferring biological samples and associated data from a procedure outsideof the research may have a condition, disease, genetic background, or trait ofinterest or serve as a healthy control and must have an available parent/guardian toprovide consent.

Exclusion Criteria:

• Wards of the state.

• For prospective skin samples: history of keloid formation, coagulation disorder, orallergy to the anesthetic.

• For prospective blood samples: history of coagulation disorder.

• For all prospective sample collections: 1) Subjects who refuse to adhere to NYSCF'sand/or a collection site's safety protocol(s) will be excluded; 2) Subjects with anAIDS diagnosis and CD4 count of less than 200 cells per microliter (mcL) of bloodwill be excluded due to increased risk of infection.