ARON-3 Study: International Multicentric Retrospective Study to Collect Global Experiences in the Treatment of Patients With Metastatic PCa

Inclusion Criteria:

• Patients aged >18y

• Cytological or Histologically confirmed diagnosis of PC

• Histologically or radiologically confirmed diagnosis of metastatic disease and

For ARON-3S

▪ Treatment with ADT + Apalutamide or ADT + enzalutamide or ADT + Abiraterone or ADT + Abiraterone + Docetaxel or ADT + Darolutamide + Docetaxel (patients treated with previous docetaxel - CHAARTED - resulted eligible)

For ARON-3Lu

▪ Treatment with Luthetium-177-PSMA therapy for castration resistant PC

For ARON-3GEN

• HRD POSITIVE STATUS

• Treatment with PARP inhibitors for castration resistant PC. Treatment included:olaparib (as 1st, 2nd or 3rd line therapy), olaparib + abiraterone (as 1st linetherapy) or niraparib + abiraterone (as 1st line therapy) or talazoparib +enzalutamide

Exclusion Criteria:

• Patients without histologically confirmed diagnosis of PC

• Patients without histologically or radiologically confirmed metastatic disease and

For ARON-3S

▪ Patients treated with doublets or triplets not included in the list reported in the Inclusion Criteria Section

For ARON-3Lu

▪ Patients treated with Luthetium-177-PSMA therapy for hormone/castration sensitive PC

For ARON-3GEN

• HRD NEGATIVE STATUS

• Patients treated with PARP inhibitors alone or in combination regimens not includedin the ARON-3GEN study