Steroid-eluting Sinus Stent for Chronic Rhinosinusitis Patients With Uncontrolled Postoperative Symptoms

Inclusion Criteria:

• The patient underwent pre-functional endoscopic sinus surgery and bilateralethmoidectomy (for at least 3 months), and was identified by the clinician as havinguncontrolled symptoms (Diagnostic criteria of EPOS 2020) with a Snot-22 score of atleast 20;
• Edema score of bilateral nasal endoscopy was 2 points both;
• Understands the purpose and procedures of the trial and voluntarily signs the informedconsent form;
• The female subjects had no pregnancy or lactation plans during the treatment andfollow-up period;
• The subject has not participated in other clinical trials in the previous three monthsand agrees not to participate in other clinical trials until the end point of thistrial was reached;
• Subjects were 18-65 years old, male or non-pregnant women;

Exclusion Criteria:

• Grade 2 or more nasal polyp scores in either nasal cavity (i.e., polyps extendingbeyond the middle nasal passage)
• The subject has a known allergic reaction or contraindication to the device materialand its degradation products (mamethasone citrate, L-polylactic acid, racemicpolylactic acid, lactide lactate, lactic acid);
• Subjects had cystic fibrosis, congenital ciliary dyskinesia, fungal globularsinusitis, systemic vasculitis and granulomatous diseases, tumors, and immunedeficiency.
• The patient underwent endoscopic nasal surgery within 3 months.
• Acute exacerbation of allergic rhinitis, acute exacerbation of CRS, upper respiratorytract infection, or common cold in the 4 weeks prior to screening visit;
• Have a clinically serious metabolic, cardiovascular, immune, neurological, blood,digestive, cerebrovascular, or respiratory disease, or any condition that theinvestigator believes interferes with the evaluation of the study results or affectsthe safety of the subjects;
• Symptomatic seasonal allergic rhinitis, and/or, depending on the season, expected todevelop symptoms and require nasal spray hormone therapy within 4 weeks ofrandomization,