Effect of Galvanic Vestibular Stimulation on Cortical Excitability and Hand Dexterity in Multiple Sclerosis Patients

Last updated: December 22, 2023
Sponsor: Cairo University
Overall Status: Active - Recruiting

Phase

1

Condition

Multiple Sclerosis

Scar Tissue

Neurologic Disorders

Treatment

MovAlyzeR® software from Neuroscript

Galvanic vestibular stimulation

BODYFIT Mini Portable Pedal Home Exerciser (cyclic ergometer)

Clinical Study ID

NCT06195644
P.T.REC/012/004742
  • Ages 20-45
  • All Genders

Study Summary

This study will be conducted to investigate the following:

  1. The impact of implementing GVS in MS rehabilitation on cortical excitability.

  2. The influence of GVS on upper limb function in patients diagnosed with MS. Patients will be randomly assigned to a control group (Conventional Physical Therapy program = CPT) and a study group (Galvanic Vestibular Stimulation = GVS in addition to the conventional program) subsequently. CPT will perform moderate intensity aerobic training (arm ergometer) and task oriented hand manipulation training, while GVS will receive Galvanic Vestibular Stimulation will be added to the conventional physical Therapy program.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients with ataxic RRMS type of both genders will be recruited. The last MS relapseoccurred at least 3 months prior to the study.
  2. Patients' age will range from 20 to 45 years old.
  3. Ambulant Patients who meet the level less than or equal to 5 on EDSS will berecruited.
  4. Patients' score on Mini Mental State Examination should be > 26.
  5. Mild or no spasticity (grade 1 or 1+) according to Modified Ashworth Scale.
  6. All patients must at least hold Primary stage certificate of education from one of theEgyptian educational authorities.
  7. All patients can independently sign consent form

Exclusion

Exclusion Criteria:

  • Patients will be excluded if they have:
  1. Moderate to severe auditory or visual or cognitive impairment.
  2. Coexistence of other neurological diagnoses of Central or Peripheral Nervoussystem (e.g. cerebrovascular stroke, vestibulopathy or polyneuropathy).
  3. History of any problems that hinder conduction of aerobic training or magneticstimulation (e.g. deep venous thrombosis, shunts and pacemakers).

Study Design

Total Participants: 40
Treatment Group(s): 3
Primary Treatment: MovAlyzeR® software from Neuroscript
Phase: 1
Study Start date:
September 03, 2023
Estimated Completion Date:
December 31, 2025

Connect with a study center

  • Cairo University

    Cairo,
    Egypt

    Active - Recruiting

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