First-in-human Safety and Immunogenicity Study of SCB-1019 and SCB-1019T in Healthy Adults

Inclusion Criteria:

1. Male and female participants 60 to 85 years of age at the screening visit.

2. Individuals willing and able to comply with study requirements, including allscheduled visits, vaccination, laboratory tests, and other study procedures.

3. Individuals willing and able to give an informed consent, prior to screening.Healthy participants as determined by medical history, physical examination, andclinical judgment of the investigator; participants with pre-existing stable medicalconditions can be included.

Exclusion Criteria:

1. Acute disease or fever (≥38°C) at time of vaccination.

2. History of a severe adverse reaction associated with a vaccine or severe allergicreaction (e.g., anaphylaxis) to any component of the study vaccines.

3. Any progressive unstable or uncontrolled clinical conditions.

4. Any progressive or severe neurologic disorder, seizure disorder, or history ofGuillain-Barré syndrome.

Please refer to Protocol for full list of Inclusion and Exclusion criteria.