OPTImal PHARMacological Therapy for Patients With Heart Failure: The OPTIPHARM-HF Registry

Last updated: December 21, 2023
Sponsor: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Failure

Chest Pain

Hyponatremia

Treatment

N/A

Clinical Study ID

NCT06192524
NP5441
  • Ages > 18
  • All Genders

Study Summary

Prospective, observational, multicenter, national study of adult patients with HF to assess prescription and adherence to evidence-based Guideline-Directed Medical Therapy (GDMT) in patients with Heart Failure (HF).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients ≥ 18 years old
  • Signed patient informed consent form (ICF)
  • Diagnosis of chronic or acute decompensated HF according to ESC guidelines and theuniversal definition of HF.
  • Receiving at least one drug for management of HF at study enrollment (includingdiuretics, β-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptorblockers, aldosterone antagonists).

Exclusion

Exclusion Criteria:

  • Planned participation or participation in a clinical trial;
  • Life expectancy < 1 year because of non-cardiac causes;
  • Previous heart transplant or left ventricular assist device implantation.

Study Design

Total Participants: 2000
Study Start date:
July 18, 2022
Estimated Completion Date:
October 01, 2025

Study Description

Prospective, observational, multicenter, national study designed to evaluate the care and outcomes of patients with HF, to understand reasons for lack of implementation of evidence-based treatment and the impact of adherence to treatment on clinical outcomes in patients with HF across the full spectrum of left ventricular ejection fraction (LVEF).

The study will enroll consecutive patients with symptomatic HF, aged ≥ 18 years from at least 30 Italian tertiary HF care centers. Both outpatients and in-patients with chronic and acute decompensated HF will be consecutively recruited. Patients will be followed for a maximum duration of 24 months.

Connect with a study center

  • ASST Spedali Civili

    Brescia, 25123
    Italy

    Active - Recruiting

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