Communication Bridge 3 Study

Last updated: December 9, 2024
Sponsor: University of Chicago
Overall Status: Active - Recruiting

Phase

2

Condition

Dementia

Speech Disorders

Frontotemporal Dementia

Treatment

Evidence-Based Impairment Focused

Communication Bridge™

Clinical Study ID

NCT06191198
IRB23-1175
7R01AG055425-07
  • Ages 18-100
  • All Genders

Study Summary

This study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild-moderate Primary Progressive Aphasia (PPA). The aim of the study is to help us better understand the effects of speech-language therapy on communication abilities in individuals with PPA.

Eligibility Criteria

Inclusion

Inclusion Criteria (person with PPA):

  1. Meets diagnostic criteria for PPA based on neurologist and supporting medicalassessments (extracted from medical records)

  2. English as primary language used in daily communication activities (by self-report)

  3. Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report)

  4. Adequate vision (aided or unaided) for reading a newspaper, or other functionalmaterials (by self-report)

  5. Able to pass technology screening and demonstrates sufficient knowledge for use ofvideo conference and Communication Bridge™ web application use (with or withouttraining)

  6. Geriatric Depression Scale score ≤ 9

  7. Mild-moderate PPA informed by a structured interview with a speech-languagepathologist and a standardized testing battery.

Inclusion Criteria (Co-enrolled communication partner):

  1. 18+ years of age

  2. English as primary language used in daily communication activities (by self-report)

  3. Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report)

  4. Able to pass technology screening* and demonstrates sufficient knowledge for use ofvideo conference and Communication Bridge™ web application use (with or withouttraining)

Exclusion

Exclusion Criteria:

  • A dementia diagnosis other than Primary Progressive Aphasia

  • Participation is co-enrolled in an outside speech language therapy program duringthe study course.

  • Communication partners will be excluded if they have a pre-existing communicationimpairment that would affect study participation (e.g., aphasia, dementia)

Medical records will be requested and reviewed to determine eligibility

Study Design

Total Participants: 200
Treatment Group(s): 2
Primary Treatment: Evidence-Based Impairment Focused
Phase: 2
Study Start date:
July 15, 2024
Estimated Completion Date:
July 15, 2028

Study Description

Participants with a diagnosis of PPA and their actively-engaged care partners will be involved in the study for approximately 17 months. Each participant will receive a laptop equipped with the necessary applications and features for the study. Participants will receive up to 10 evaluations and 20 speech therapy sessions with a licensed speech therapist, as well as access to Communication Bridge, a personalized web application to practice home exercises that reinforce treatment strategies. There are no costs to participate in this study.

Connect with a study center

  • University of Chicago - American School Building

    Chicago, Illinois 60637
    United States

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.