Testing an Intervention in Irritative Contact Dermatitis

Last updated: December 18, 2023
Sponsor: University of Split, School of Medicine
Overall Status: Active - Recruiting

Phase

N/A

Condition

Allergy

Rash

Dermatitis, Atopic

Treatment

no treatment

Emollient cream treatment

Clinical Study ID

NCT06189144
2181-L98-03-04-23-0030
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

An eczematous reaction is an inflammatory intolerance response of the skin. In acute phase the reaction is characterized by erythema and blistering while in the chronic phase it presents as dryness, itchiness and lichenification. Irritative contact dermatitis describes these patterns of reaction in response to toxicity of chemicals on the skin cells, which trigger inflammation by activation of the innate immune system.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • healthy volunteers who gave written informed consent

Exclusion

Exclusion Criteria:

  • · skin cancer
  • skin disease
  • skin damage on measurement sites
  • use of corticosteroids, antihistamines and immunomodulators a month prior theinclusion and during the trial
  • use of drugs that may cause photosensitivity
  • use of emollients three days prior the inclusion in the trial
  • non-adherence to the trial protocol
  • exposure to artificial and excessive natural ultraviolet (UV) radiation
  • pregnancy and lactation
  • history of vitiligo, melasma and other pigmentation and photosensitivitydisorders
  • immunosuppression
  • allergic or irritant reactions to the constituents of the cream

Study Design

Total Participants: 25
Treatment Group(s): 2
Primary Treatment: no treatment
Phase:
Study Start date:
June 01, 2023
Estimated Completion Date:
June 01, 2024

Study Description

An eczematous reaction is an inflammatory intolerance response of the skin. In acute phase the reaction is characterized by erythema and blistering while in the chronic phase it presents as dryness, itchiness and lichenification. Irritative contact dermatitis describes these patterns of reaction in response to toxicity of chemicals on the skin cells, which trigger inflammation by activation of the innate immune system. Therefore, the aim of this study was to see if omega cream, as proposed by its mechanism of action, could improve SLS induced contact dermatitis.

Connect with a study center

  • School of Medicine

    Split, 21000
    Croatia

    Active - Recruiting

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