Time-restricted Eating in Peri- and Postmenopausal Women

Inclusion Criteria:

• Healthy women aged 40-58 years
• Perimenopausal or recently postmenopausal, >1 year and <5 years
• BMI > 30 kg/m2
• Dyslipidemic, defined as the presence of one or more lipid-based cardiovasculardisease risk-enhancing factors per American College of Cardiology/American HeartAssociation guidelines
• Normal renal and hepatic function
• Perimenopausal women, a negative pregnancy test

Exclusion Criteria: Dietary factors:

• Diagnosis, or strong clinical suspicion, of eating disorders, including but notlimited to, anorexia nervosa, bulimia nervosa, binge eating disorder
• Concurrent dietary intervention or modification unrelated to study procedures Psychiatric factors:
• Current major depressive episode
• Suicidal ideation
• Lifetime history of bipolar disorder, psychosis, or other serious mental healthproblem
• Current alcohol/substance use disorder Medical factors:
• Use of lipid-lowering or lipid-enhancing medications
• Use of systemic hormonal (estrogens and/or progestin) therapies
• Use of weight loss medications or supplements
• Use of medications that may cause weight loss or gain, unless body weight andmedication usage remained stable for at least 6 months
• Previous weight loss surgery
• Abnormal vital signs at screening visit
• Body weight > 350 pounds, per DXA scan limits
• Malignancy within past 2 years
• Major surgery within past 3 months
• Medical instability considered to interfere with study procedures
• Contraindications to DXA scanning
• Use of medications that have the potential to cause hypoglycemia (e.g., insulin,sulfonylureas)
• Undergoing treatment for cancer
• Use of medications for which time-restricted eating would interfere with recommendedtiming of medication ingestion with food intake. Lifestyle and other factors:
• Irregular sleep/wake schedule
• Shiftwork
• Recent travel across 2 or more time zones
• Recent change in exercise habits
• Work or social schedules that would impede ability to adhere to study protocol Adherence factors:

-Inability to adhere to study procedures completed between screening and randomizationvisits Off-Study Criteria:

• Initiation of new medications for lipid management, weight loss, hormonal medications,or other medications that may cause changes in weight or lipid levels
• Development of any significant medical problem
• Enrollment in another clinical trial involving study procedures or medications thatmight interfere with study procedures.
• Significant deviation from study protocol or protocol violation
• Inability to adhere to time-restricted eating window