Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis

Last updated: December 12, 2023
Sponsor: Universität des Saarlandes
Overall Status: Active - Recruiting

Phase

N/A

Condition

Kidney Failure

Kidney Disease

Renal Failure

Treatment

DKK-3

Clinical Study ID

NCT06180551
IMED IV-001
  • Ages > 18
  • All Genders

Study Summary

Critically ill patients are at risk of developing a sudden decrease of kidney function which may be detected by a decrease in urine output or is diagnosed on the basis of blood tests for substances normally eliminated by the kidney, primarily creatinine.

Because it takes about 24 hours for the creatinine level to rise, even if both kidneys have ceased to function, better markers are needed.

This trial is investigating if the marker urinary dickkopf-3 (uDKK3) allows an early prediction of a sudden decrease of kidney function.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients treated on the intensive care units of Saarland University Hospital.

Exclusion

Exclusion Criteria:

  • Patients on renal replacement treatment before admission to the intensive care unit.
  • Patients with chronic kidney disease stage CKD G3b or below.
  • Known kidney disease.
  • Kidney transplantation.
  • Intoxications leading to dialysis treatment.
  • Participation in other clinical trials.

Study Design

Total Participants: 1000
Treatment Group(s): 1
Primary Treatment: DKK-3
Phase:
Study Start date:
December 01, 2023
Estimated Completion Date:
June 30, 2027

Study Description

Urinary dickkopf-3 (uDKK3), a stress-induced renal tubular epithelium-derived glycoprotein, has been identified as a biomarker predicting persistent kidney dysfunction.

In this prospective observational trial in patients at high risk of developing acute kidney injury we will assess whether urinary dickkopf-3 serves as a predictor of acute kidney injury.

Patients of the intensive care units of Saarland University Hospital will be surveyed for up to two years after their admission to the intensive care unit.

The progression of the estimated Glomerular Filtration Rate and uDKK3 will be monitored.

Connect with a study center

  • Universitätsklinikum des Saarlandes

    Homburg, Saarland 66421
    Germany

    Active - Recruiting

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