M108 Plus CAPOX Versus Placebo Plus CAPOX as First-line Treatment for Claudin (CLDN) 18.2-Positive, HER2-Negative, PD-L1 CPS<5, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma.

Inclusion Criteria:

1. Written informed consent
2. Histologically confirmed diagnosis of locally advanced unresectable or metastaticgastric/GEJ adenocarcinoma with no treatment previously. For patients withneoadjuvant/adjuant chemotherapy in the past, duration of last therapy to recurrenceshould be more than 6 months
3. At least 1 measurable site of the disease according to RECIST 1.1 criteria.
4. Positive CDLN 18.2 expression
5. Negative HER2 expression, PD-L1 CPS<5
6. ECOG performance status (PS) 0-1
7. Life expectancy > 3 months
8. Age ≥ 18 years and ≤75 years
9. Adequate haematological/ coagulation/ hepatic/ renal function
10. Men and women of childbearing age should agree to use effective contraception from thetime they sign their informed consent until 3 months after the last dosing. Femalesubjects of childbearing age must have a negative blood beta-HCG test within 72 hoursprior to first dosing.

Exclusion Criteria:

1. Previous radiotherapy within 4 weeks prior to the start of study treatment. (ifpalliative radiotherapy was given to bone metastases and the patient recovered fromacute toxicity was allowed).
2. Previous anti-tumor therapy within 4 weeks prior to the start of study treatment.
3. Previous major operation within 4 weeks prior to the start of study treatment.
4. Have a prior severe allergic reaction or intolerance to known components of M108monoclonal antibodies or other monoclonal antibodies (including humanized or chimericantibodies); Allergic or intolerant to any component of capecitabine, oxaliplatin,etc.
5. Subject who has been treated with CLDN18.2 monoclonal/bispecific antibodies, CLDN18.2CAR-T, CLDN18.2 ADC and any therapies that target CLDN18.2.
6. Subject who is in pregnant or in lactation period.
7. Other clinically significant disease which may have adversely affected the safedelivery of treatment within this study.