ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)

Inclusion Criteria:

• BMI 30.0 - 50.0 kg/m2

• Able to attend study intervention classes and study visits/assessments

• Independently living with access to food preparation facilities

Exclusion Criteria:

• Current smoker or regular use of nicotine containing products and/or cannabis

• Heavy alcohol use (≥2 drinks/d for females, ≥3 drinks/d for males) or drug use

• Known cognitive impairments or h/o stroke

• Type 2 diabetes (known diagnosis or by screening A1c (≥6.5%))

• Medical conditions (chronic diseases, cancer, MS) or labs limiting ability toparticipate

• Females: currently pregnant (or 6-months postpartum of full-term pregnancy) and/orcurrent breastfeeding

• Use of medications with significant effects on appetite (e.g., weight lossmedications, atypical antipsychotics, stimulants) and/or chronic use ofanticoagulants

• History of bariatric surgery

• History of eating disorder

• Current participation in a formal weight loss program

• Prior or current participation in a research study involving weight loss

• Weight-reduced by >10% within past year

• Weight > 330 pounds (MRI limit)

• Allergy or intolerance to or unwillingness to consume study foods provided at visit

• MRI contraindication (e.g., implanted metal, claustrophobia)

• Do not have a phone compatible with activity tracker or access to videoconferencingplatform that will be used for the dietary intervention or other appropriatetechnology needed to complete study procedures

• Any condition(s) found by the study team and confirmed with the PI(s) that make itunsafe to participate