The Role of Granulocyte Colony Stimulating Factor in Embryo Transfer Outcomes

Last updated: March 19, 2024
Sponsor: Newlife Fertility Centre
Overall Status: Active - Recruiting

Phase

4

Condition

Infertility

Treatment

Granulocyte Colony-Stimulating Factor (Filgrastim)

Standard Embryo Transfer Media

Clinical Study ID

NCT06174298
NFC-2023-001
  • Ages 18-38
  • Female

Study Summary

The goal of this clinical trial is to test the effect of granulocyte colony-stimulating factor (G-CSF, A.K.A. Filgrastim) in infertility patients undergoing in vitro fertilization (IVF) treatment. The main question it aims to answer is:

Can in vitro fertilization-embryo transfer (IVF-ET) outcomes be improved by supplementing the transfer media with Granulocyte colony-stimulating factor (GCSF)?

Participants will undergo their embryo transfer as per the normal clinic protocol but will be randomized to either receive the standard embryo transfer media or the GCSG-supplemented transfer media.

Researchers will compare the GCSF and standard transfer media groups to see if clinical outcomes are improved (i.e., implantation rate, pregnancy, clinical pregnancy rate, live birth rate).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Recruited subjects will either be undergoing a fresh IVF-ET cycle in which theembryo(s) generated from the initial treatment cycle are transferred during that samecycle (i.e., on day 5 or 6 post-egg retrieval) or an FET cycle in which the embryo(s)transferred were generated in a previous IVF cycle and were cryopreserved forsubsequent warming and transfer.

Exclusion

Exclusion Criteria:

  • Patients with uterine factor or severe male factor infertility will be excluded.
  • Patients who have had previous IVF failures will be excluded.

Study Design

Total Participants: 300
Treatment Group(s): 2
Primary Treatment: Granulocyte Colony-Stimulating Factor (Filgrastim)
Phase: 4
Study Start date:
March 20, 2024
Estimated Completion Date:
January 10, 2025

Study Description

Please see uploaded study protocol.

Connect with a study center

  • Newlife Fertility Centre

    Mississauga, Ontario L4Z 2G6
    Canada

    Active - Recruiting

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