A Study of Glipizide to Treat High Blood Sugar in People With Pancreatic Cancer

Inclusion Criteria:

Cohort 1

• Age ≥18 years

• Biopsy-proven PDAC

• Radiological evidence and clinical assessment that patient has active disease (local, locally advanced, or metastatic)

• Willing and able to comply with the requirements of the protocol

• Willing to use their bluetooth-enabled wifi or cellular mobile device

• Hemoglobin A1c (HbA1c) > 7%, or fructosamine > 287 mg/dL, or random glucose > 180mg/dL, or strong clinical suspicion that patient has hyperglycemia, making itreasonable to expect their mean daily glucose is ≥154 mg/dL

• Eastern Cooperative Oncology Group performance status ≤2

• BMI <30 kg/m2

Cohort 2a

• Age ≥18 years

• Biopsy-proven PDAC

• Radiological evidence and clinical assessment that patient has active disease (local, locally advanced, or metastatic pancreatic cancer)

• Clinical diagnosis of diabetes mellitus

• Active care at MSK (defined as at least 1 physician or APP encounter every 3 months)for PDAC during the period from which data were recorded in the electronic medicalrecord (in this retrospective study patients need not be under active care at thetime the research is conducted)

• At least 1 electronic prescription for a sulfonylurea (glipizide, glimepiride, orglyburide) or metformin

• Three-month baseline period before metformin or sulfonylurea initiation in which theparticipant does not receive either drug class or insulin

• Body weight recorded within 3 months before start of metformin or a sulfonylurea

Cohort 2b

• Age ≥18 years

• Biopsy-proven PDAC

• Radiological evidence and clinical assessment that patient has active disease (local, locally advanced, or metastatic)

• Active care at MSK (defined as at least 1 physician or APP encounter every 3 months)for PDAC during the period of data collection

• Apparent current use based on chart review of metformin (but not sulfonylurea);sulfonylurea (but not metformin); or neither drug

Exclusion Criteria:

Cohort 1

• Use during the past month of any antidiabetic medication other than metformin athome (sporadic use [fewer than 1 of 7 days during the past month] is permitted)

• Changes in metformin dose in the past month

• History of sulfonylurea intolerance or allergy

• History of severe hypoglycemia (hypoglycemia requiring emergency medical assistance,emergency room or urgent care visit, or hospital admission)

• AST or ALT >3 x upper limit of normal

• Glomerular filtration rate <30 mL/min/1.73m2

• Daily chronic use of any dose of corticosteroids (as distinct from intermittentexposure to steroids as part of cyclic chemotherapy)

• Inability to wear CGM

Cohort 2a

• Greater than trace ascites documented on imaging or physical exam

Cohort 2b

• Greater than trace ascites documented on imaging or physical exam