Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception

Last updated: May 30, 2025
Sponsor: Aalborg University
Overall Status: Completed

Phase

N/A

Condition

N/A

Treatment

Cowhage

Histamine

Clinical Study ID

NCT06154824
N-20210046 1st project
  • Ages 18-60
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

In This experiment, the investigators would like to test following hypotheses:

repetitive cutaneous administration of pruritogens will lead to a more robust and longer lasting itch sensation compared with a single application. The aim of this project is to investigate a new itch model based on repetitive administration of three different pruritogens: histamine (histaminergic itch), cowhage, and BAM 8-22 (non-histaminergic itch).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy men and women

  • 18-60 years

  • Speak and understand English

Exclusion

Exclusion Criteria:

  • Pregnancy or lactation

  • Drug addiction defined as any use of cannabis, opioids, or other addictive drugs

  • Previous or current history of neurological (e.g. neuropathy), immunological (e.g.asthma, immune deficiencies, arthritis) musculoskeletal (e.g. muscular pain in theupper extremities,), cardiac disorder, or mental illnesses that may affect theresults

  • Lack of ability to cooperate

  • Current use of medications that may affect the trial such as antihistamines,antipsychotics, and pain killers, as well as systemic or topical steroids

  • Skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis)

  • Moles, scars, or tattoos in the area to be treated or tested.

  • Consumption of alcohol or painkillers 24 hours before the study days and betweenthese

  • Acute or chronic pain

  • Participation in other trials within one week of study entry (four weeks in the caseof pharmaceutical trials)

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: Cowhage
Phase:
Study Start date:
December 15, 2023
Estimated Completion Date:
May 30, 2025

Study Description

Chronic itch affects approximately a fifth of the global population and is associated with substantial negative consequences for the affected individuals. Furthermore, there is a lack of efficient treatment options for chronic itch. In order to mimic a clinical itch condition as presented in patients, the aim of the project is to investigate a new itch model based on repetitive administration of three different pruritogens: histamine (histaminergic itch), cowhage, and BAM 8-22 (non-histaminergic itch). The hypothesis is that repetitive cutaneous administration of pruritogens will lead to a more robust and longer-lasting itch sensation compared with a single application. This proposal for a new itch model could better mimic clinical itch conditions and be used to investigate fundamental mechanisms, new anti-pruritic drugs, and their possible mechanisms of action.

Connect with a study center

  • Aalborg University

    Aalborg, 9260
    Denmark

    Site Not Available

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