Eyelid Androgen Treatment in Dry Eye

Inclusion Criteria:

• Moderate to severe dry eye (TBUT < 6.0 seconds, corneal staining > grade 1.5,evidence of meibomian gland secretion compromise or Schirmer < 5 mm wetting in 5minutes)

• Age over 18

• Mild ectropion

• Previous contact lens wearers IF no wear for prior 6 months

• Punctal plugs if more than three months since placement

• Systemic tetracyclines, antihistamines if consistent dosing

• Sjogren's syndrome and related autoimmune conditions can be enrolled

• Patients using topical dry eye treatments (e.g., Restasis) if willing to discontinuefor 30 days

Exclusion Criteria:

• If artificial tears or autologous serum used on day of study

• Ocular surgery if less than 12 months

• Punctal plugs if within 3 months of plug insertion

• Contact Lens wear within the six months prior to study

• PSA levels greater than 4 ng/ml or BPH

• Recent or current thrombolism

• Recent or current cardiovascular events (e.g., MI, stroke)

• Recent or current liver disorders

• Concurrent use of topical medications; e,g., topical glaucoma medications

• Diabetics

• Females of child-bearing age if not on reliable birth control

• History of breast cancer

• Cannot be taking insulin, warfarin or systemic corticosteroids