A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure

Inclusion Criteria:

• Current symptom(s) of HF NYHA class II-III and LVEF < 50%

• Elevated NT-proBNP levels at screening.

• Receiving standard of care background HF therapy.

Exclusion Criteria:

• Current acute decompensated HF or hospitalization for HF within 3 months prior toscreening.

• Current symptomatic hypotension (for example dizziness/presyncope).

• K+ > 5.4 mmol/L at screening

• eGFR < 30 mL/min/1.73m2 at screening

Other protocol-specific criteria may apply.