A Study of the Zanubrutinib Given in Combination With Bendamustine and Rituximab in (Elderly or TP53 Alterations or Chemotherapy Intolerance) Patients With Newly Diagnosed Mantle Cell Lymphoma

Inclusion Criteria:

• 18 years
• Histopathologically confirmed mantle cell lymphoma according to the 5th editionof the World Health Organization (WHO)
• FISH with del(17p)/TP53 mutation or ≥65 years; or<65 years but chemotherapyintolerance;
• Life expectancy of > 3 months (in the opinion of the investigator);
• Creatinine Clearance Rate (CCR) ≥ 50 mL/min or estimated Glomerular Filtration ●Rate (eGFR) ≥ 60 mL/(min·1.73 m^2);
• International Normalized Ratio (INR) ≤ 1.5 and activated Partial ThromboplastinTime (aPTT) ≤ 1.5 times the upper limit of normal;
• Left Ventricular Ejection Fraction (LVEF) ≥ 50%;
• Agreeing to provide written informed consent prior to any special examination orprocedure for the research on their own or legal representative.

Exclusion Criteria:

• Pregnant or lactating women;
• Known Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV) infection (HBV infectionrefers to HBV-DNA > detectable limit);
• With acquired or congenital immunodeficiency;
• With congestive heart failure in 6 months before enrollment, New York HeartAssociation (NYHA) heart function class III or IV, or LVEF < 50%;
• Known to be allergic to the test drug ingredients;
• Diagnosed with or being treated for malignancy other than lymphoma;
• With severe infection;
• Substance abuse, medical, psychological, or social conditions that may interfere withthe subjects' participation in the study or evaluation of the study results;
• Deemed unsuitable for the group.