Transcutaneous Vagus Nerve Stimulation for Generalized Anxiety Disorder

Inclusion Criteria:

• Meeting DSM-5 diagnostic criteria for Generalized Anxiety Disorder;
• Having a first episode of Generalized Anxiety Disorder or not having used ananxiolytic, antidepressant, antipsychotic, or anticonvulsant medication in the last 1month.
• Having a Hamilton Anxiety Scale (HAMA) score of more than 14 and a Hamilton DepressionScale (HAMD-17) score of less than 17.

Exclusion Criteria:

• Having organic brain lesions (e.g., cerebral hemorrhage, massive cerebral infarction,encephalitis, epilepsy); cardiac QTc interval > 450ms;
• Current or previous diagnosis of other major diseases (e.g., coronary heart disease,pulmonary heart disease, etc.)
• Currently or previously diagnosed with a mental disorder other than anxiety disorder (except for insomnia disorder);
• Those who are participating or have participated in vagus nerve stimulation therapy;those who are participating in transcranial magnetic stimulation or transcranialdirect current therapy;
• Pregnant, breastfeeding, or planning to become pregnant during the trial;
• Refusing to sign the informed consent form.