A Study to Evaluate Biomarker Signature to Predict the Persistence of Post-traumatic Headache

Inclusion Criteria:

• Post-traumatic headache (PTH) and persistent post-traumatic headache (PPTH) will bediagnosed using the ICHD-3 diagnostic criteria for PTH attributed to mild traumaticbrain injury (concussion).

• For patients with PTH, only patients with new onset of PTH without history of PPTHwill be included in the study.

• A personal history of prior concussion and history of migraine are allowed accordingto ICHD-III diagnostic criteria.

• Tension-type headaches on three or fewer days per month is allowed for healthycontrol subjects.

Exclusion Criteria:

• History of moderate or severe traumatic brain injurie (TBI).

• Prior history of gross anatomical change on imaging.

• Contraindication to MRI, including but not limited to severe claustrophobia and/orpresence of ferrous materials in the body.

• Women who are pregnant, or believe that they might be pregnant. Although there areno known contraindications or risks associated with pregnancy and MRI, we willexclude pregnant women or women who believe that there might be a chance that theyare pregnant.

• History of concussion or more severe TBI.

• History of migraine or other headaches.

• The diagnosis for PTH and PPTH will be verified by Dr. Schwedt (co-investigator) aboard-certified physician in Neurology and Headache Medicine. Presence of concussionwill be verified using the Ohio State University TBI Identification Method, astandardized questionnaire assessing the lifetime history of TBI for an individual.