MAXPIRe: Study to Evaluate Axatilimab in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Key Inclusion Criteria:

• Documented diagnosis of IPF per the 2018 American Thoracic Society (ATS)/EuropeanRespiratory Society (ERS)/Japanese Respiratory Society (JRS)/Latin American ThoracicSociety Clinical Practice Guideline (Raghu 2018).

• Chest high-resolution computed tomography (HRCT) performed within 12 months prior tofirst Screening Visit and according to the minimum requirements for IPF diagnosis bycentral review based on participant's HRCT only (if no lung biopsy is available) orbased on both HRCT and lung biopsy (with application of the different criteria ineither situation). If an evaluable HRCT <12 months prior to Screening is notavailable, an HRCT can be performed at first Screening Visit to determineeligibility, according to the same requirements as the historical HRCT. If aparticipant has an indeterminate usual interstitial pneumonia (UIP) pattern andtheir HRCT is >6 months old, if in the opinion of the Investigator their disease hasprogressed, an additional HRCT may be obtained and reviewed for eligibility.

• FVC ≥45% of predicted normal at Screening Visits.

• Forced expiratory volume in 1 second (FEV1)/FVC ≥0.7 at Screening Visits.

• DLco ≥30% and ≤90% of predicted, corrected for hemoglobin at first Screening Visit.

Key Exclusion Criteria:

• Abnormalities detected on electrocardiogram (ECG) of either rhythm or conductionthat in the opinion of the Investigator are clinical significant. Participants withimplantable cardiovascular devices (for example, pacemaker) affecting the QTinterval time may be enrolled in the study based upon Investigator judgmentfollowing cardiologist consultation if deemed necessary, and only after discussionwith the Medical Monitor.

• Emphysema present on ≥50% of the HRCT, or the extent of emphysema is greater thanthe extent of fibrosis, according to central review of the HRCT.

• Interstitial lung disease associated with known primary diseases (for example,connective tissue disease, sarcoidosis and amyloidosis), exposures (for example,radiation, silica, asbestos, and coal dust), or drugs (for example, amiodarone).

• Participants who cannot meet protocol-specified baseline stability criteria.

• Acute IPF exacerbation within 3 months prior to screening.

• Receiving nintedanib in combination with pirfenidone

• Receiving systemic corticosteroids equivalent to prednisone >10 milligrams (mg)/dayor equivalent within 2 weeks prior to Screening.

• Use of any of the following therapies within 4 weeks prior to Screening and duringthe Screening Period, or planned during the study: imatinib, ambrisentan,azathioprine, mycophenolate mofetil, cyclophosphamide, cyclosporine A, tacrolimus,bosentan, methotrexate, inhaled treprostinil, phosphodiesterase-5 inhibitors,including sildenafil (unless for occasional use), prednisone at steady dose >10mg/day or equivalent, or other investigational therapy.

• History of cigarette smoking or vaping within the previous 3 months.

• Female participant who is pregnant or breastfeeding.

• Previous exposure to study intervention or known allergy/sensitivity to study drug.

• Receiving an investigational treatment within 28 days of randomization.

• Inadequate IV access.