Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas

Inclusion Criteria:

1. Adult ≥18 years of age
2. Have a diagnosis of NF1 based on germline genetic testing or by meeting ≥ 2 thefollowing criteria:
3. Family history of NF1
4. Six or more light brown ("cafe-au-lait") spots on the skin
5. Presence of two or more neurofibromas of any type, or one or more plexiformneurofibromas
6. Freckling under the arms or in the groin area
7. Two or more pigmented, benign bumps on the eye's iris (Lisch nodules)
8. A distinctive bony lesion: dysplasia (abnormal growth) of the sphenoid bonebehind the eye, or dysplasia of long bones, often in the lower leg
9. Tumor on the optic nerve that may interfere with vision
10. Patients must be seeking treatment for cNF
11. Patients must have ≥ 6 paired cNF (3 to be treated and 3 untreated) that are visibleand measure between 2-8mm in size. These must be in areas amenable to treatment andsurveillance with digital photography.
12. cNF must be located on the trunk, arms or legs of the patient
13. Able and willing to comply with all visit, treatment and evaluation schedules andrequirements
14. Able to understand and provide written informed consent

Exclusion Criteria:

1. Individuals who cannot give informed consent or adhere to study schedule.
2. Actively tanning during the course of the study.
3. Adverse reactions to compounds of any external agent (e.g., gels, lotions oranesthetic creams) required for use in the study, if no alternative to the said agentexists;
4. Known allergy to injectable anesthetics, deoxycholic acid or polidocanol.
5. Women who are pregnant.
6. Those with acute thromboembolic diseases.
7. Those with bleeding abnormalities or those who are currently being treated withantiplatelet or anticoagulant therapy.
8. Those with dysphagia.
9. Any condition which, in the Investigator's opinion, would make it unsafe (for theparticipant or study personnel) to treat the participant as part of this researchstudy.