Effect of NUTRICAN to Improve Nutritional Status in Cancer Patients

Inclusion Criteria:

• Histologically confirmed lung and ob-gyn cancer patients (who have not undergonetherapy or are currently undergoing therapy)

• Aged greater than or equal to 18 years

• Patients with a performance status score of 0 - 2

• Have inadequate food intake >5 days or:

1. BMI/body mass index <18.5 kg/m2 or

2. There is a >10% weight loss in the last 3-6 months or

3. BMI <20 kg/m2 or

4. There is >5% weight loss in the last 3-6 months with

• Intervention group subjects are willing to take ONS orally for 8 weeks

• Intervention group subjects, if they have taken other brands of ONS, are willing tostop taking ONS 2 weeks prior to the study.

Exclusion Criteria:

• Pregnant and breastfeeding, except for female subjects with one of the followingcriteria:

1. Have a history of hysterectomy (surgical removal of the uterus) and/orbilateral oophorectomy (surgical removal of the ovaries).

2. Medically confirmed ovarian failure (decreased ovarian function)

3. Achieved post menopausal status, defined as: cessation of regular menstruationfor at least 12 consecutive months in the absence of pathological orphysiological causes.

• Renal insufficiency (eGFR ( Estimated Glomerular Filtration Rate ) <15 mL/min/1.73m2 or significant increase in urea/creatinine or having to be on a low protein diet)

• Liver insufficiency (SGOT (Serum Glutamic Oxaloacetic Transaminase) /SGPT (SerumGlutamic Pyruvic Transaminase) values ≥3 times the normal limit)