Incidence and Clinical Impact of Serum Hyperamylasemia (POH) After Pancreatectomy on Postoperative Outcome and Patient Safety

Last updated: February 24, 2025
Sponsor: Technische Universität Dresden
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pancreatitis

Treatment

Pancreatectomy

Clinical Study ID

NCT06126601
VTG-14
DRKS00031860
  • Ages 18-85
  • All Genders

Study Summary

Recent evidence suggests that postoperative hyperamylasemia (POH) is a predictor of morbidity after pancreatectomy. This is based on the assumption that pancreatitis after pancreatectomy (PPAP) is a major trigger for the development of complications and is indicated by hyperamylasemia. Standardized prospective analysis and correlation with other laboratory parameters, hasn't been performed to date.

Therefore the overall study aims are:

  • To prospectively evaluate the incidence and assess the clinical value of biochemical changes for the postoperative course.

  • To confirm and improve the definition and classification of postpancreatectomy acute pancreatitis (PPAP) of the International Study Group of Pancreatic Surgery (ISGPS) and to provide knowledge for effective early management of complications.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • All patients undergoing pancreatic resection for malignant and benign disease withor without pancreatic anastomosis

  • Patients aged 18-85 years

  • Willingness to participate as demonstrated by giving a written informed consent.

Exclusion

Exclusion Criteria:

  • Necrosectomy (endoscopic or open) for primary acute pancreatitis or withinlaparotomy

  • Age less than 18 years

  • Surgical drainage procedures without pancreatic resection (cystojejunostomy forpancreatic pseudocysts)

  • One-stage total pancreatectomy

  • Missing written consent

Study Design

Total Participants: 150
Treatment Group(s): 1
Primary Treatment: Pancreatectomy
Phase:
Study Start date:
July 18, 2023
Estimated Completion Date:
April 30, 2026

Connect with a study center

  • University Hospital Dresden, Dept. Visceral, Thoracic and Vascular Surgery

    Dresden, 01307
    Germany

    Active - Recruiting

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