Chronic Migraine Prophylaxis: Ultrasound-Guided Greater Occipital Nerve Block Versus Medical Treatment

Last updated: November 7, 2023
Sponsor: Tanta University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Migraine And Cluster Headaches

Oral Facial Pain

Migraine (Pediatric)

Treatment

Medical Treatment

Greater Occipital Nerve Block

bupivacaine or onabotulinum toxin A injection.

Clinical Study ID

NCT06122545
35459/4/22
  • Ages > 18
  • All Genders

Study Summary

The aim of this work is to assess the efficacy of ultrasound guided greater occipital nerve block either by local anesthetic or by botulinum toxin in comparison to medical treatment in prevention of chronic migraine.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age > 18 years old.
  2. Both sexes.
  3. Patients with chronic migraine.

Exclusion

Exclusion Criteria:

  1. Age less than 18 years.
  2. Patients with medication overuse headache.
  3. Patients who had used acute pain medications within 24 hours prior to the study visit.
  4. History of injury to the area of the GON.
  5. Any prior adverse reactions to local anesthetics.
  6. Patients with impaired sensation in the occipital area.
  7. Any neurological or dermatological disease that may have affected skin sensation,bleeding tendency, any skull defect.

Study Design

Total Participants: 80
Treatment Group(s): 3
Primary Treatment: Medical Treatment
Phase:
Study Start date:
May 01, 2022
Estimated Completion Date:
May 01, 2024

Study Description

Primary headache disorders, particularly migraine and tension-type headache (TTH) are common worldwide and commonly result in widespread and substantial disability. Chronic migraine (CM) is defined as "headache occurring on 15 or more days per month for more than 3 months which has the features of migraine headache on at least 8 days per month".

The prevalence of CM in the general population is about 2%. It negatively affects emotional and family relationships, education, economic status, and general health. Migraine headaches might become quite severe and incapacitating for patients and management can be challenging even in experienced clinics.

Prophylactic interventions may include pharmacotherapy, behavioral therapy, physical therapy and other strategies. Management often requires the simultaneous use of these different therapeutic modalities. Once the headaches become refractory to conventional pharmacologic management minimally invasive techniques such as peripheral nerve blocks are feasible for pain relief and help to decrease the frequency of the attacks.

Preventive medications for chronic migraine treatment are less well studied than they are for episodic migraine. In addition, some trials evaluating treatment of chronic migraine are limited by one or more methodologic problems, such as small size, concomitant use of other prophylactic medications and/or lack of a specific headache diagnosis.

Connect with a study center

  • Tanta University

    Tanta, El-Gharbia 31527
    Egypt

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.