Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF)

Last updated: August 4, 2025
Sponsor: Weill Medical College of Cornell University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Congestive Heart Failure

Heart Failure

Chest Pain

Treatment

I-TRANSFER-HF

Clinical Study ID

NCT06118983
23-06026204
R01HL169312
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study is trying to improve the hospital-to-home transition for people with heart failure who receive home care services. The study will test an intervention called I-TRANSFER-HF, which differs from usual care by combining early home health nurse visits and outpatient medical appointments.

The study is interested in two questions:

  1. Is I-TRANSFER-HF better than usual care at preventing heart failure patients from returning to the hospital within 30 days?

  2. Are there parts of I-TRANSFER-HF that are easy or hard to implement in the real world?

The researchers will answer these questions by testing the intervention among pairs of hospitals and home health agencies across the country. During the study, the hospital-agency pairs will be asked to implement I-TRANSFER-HF. The researchers will then compare the results from before and after I-TRANSFER-HF was adopted. They will also interview people from these hospitals and agencies to see how I-TRANSFER-HF is being implemented under real-world conditions.

Eligibility Criteria

Inclusion

Aim 1, Inclusion Criteria:

  • Adults hospitalized for HF who transition from participating hospitals to theirpartner HHC agency during the study period.

Exclusion

Aim 1, Exclusion Criteria:

  • Patients hospitalized for HF and discharged: home without HHC, or to an inpatientrehabilitation facility, skilled nursing facility, or hospice; patients with endstage renal disease on dialysis and those with left ventricular devices.

Aim 2, Inclusion Criteria:

  • Healthcare professional involved in the transition of heart failure patients fromthe acute care setting (hospital) to HHC (home health care) agencies, and theimplementation of the I-TRANSFER-HF at one of the four participating hospital-HHCdyads.

Aim 2, Exclusion Criteria:

  • Healthcare professional not involved in the transition of heart failure patientsfrom the acute care setting (hospital) to HHC (home health care) agencies, and theimplementation of the I-TRANSFER-HF at one of the four participating hospital-HHCdyads.

Study Design

Total Participants: 1094
Treatment Group(s): 1
Primary Treatment: I-TRANSFER-HF
Phase:
Study Start date:
July 01, 2026
Estimated Completion Date:
July 01, 2028

Study Description

The investigators' will test two hypotheses:

Hypothesis 1 (H1): Compared to usual care, adults with heart failure who receive the I-TRANSFER-HF intervention will have fewer 30-day readmissions, ED visits, and greater days at home. The four hospital-agency pairs will all begin the study with a baseline period of no intervention and then randomly selected to start the intervention phase at different points in time. Medicare claims data from each hospital-agency pair will be used to determine outcomes, and these data will be supplemented with national claims data for external controls not in the study to test the effectiveness of the I-TRANSFER-HF intervention.

Hypothesis 2 (H2): Compared to usual care, heart failure patients who receive I-TRANSFER-HF will have a higher proportion of timely first week HHC nursing visits (within 2 days of hospital discharge, plus 2 more) and outpatient visits (within 7-days of discharge). Given the rise of telemedicine, the study will test the association between the type of outpatient visit (in-person vs. virtual), its timing, and its association with outcomes. H2 requires conducting qualitative interviews with key stakeholders across the 4 hospital-agency pairs to identify barriers and facilitators that influence I-TRANSFER-HF's implementation. The study will assess the intervention's acceptability, feasibility, fidelity, and adaptation with interviews and Medicare claims data using a multi-methods approach and guided by the updated Consolidated Framework for Implementation Research (CFIR 2.0).

Connect with a study center

  • VNS Health Partners in Care

    New York, New York 10017
    United States

    Active - Recruiting

  • Weill Cornell Medicine

    New York, New York 10021
    United States

    Active - Recruiting

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