Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma

Inclusion Criteria:

1. Age: 20-45 years.

2. Women with uterine leiomyoma (sub-mucous, sub-serous or intramural) based ontransvaginal sonography criteria. Uterine fibroids most often appear as concentric,solid, hypoechoic masses. This appearance results from the prevailing muscle, whichis observed at histologic examination. These solid masses absorb sound waves andtherefore cause a variable amount of acoustic shadowing.

3. Regular menstruation: regular period interval from 21 to 35 days.

Exclusion Criteria:

1. Pregnant or menopausal women.

2. History of malignancies, metabolic, hematologic, cardiac, thromboembolism, diabetes,renal or hepatic diseases.

3. History of hormonal drug use or treatment for leiomyoma in the past 3 months.