Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter, Cohort Study

Last updated: December 27, 2024
Sponsor: First Affiliated Hospital of Zhejiang University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pneumonia

Treatment

metagenomics

Metagenomics

Clinical Study ID

NCT06114784
IIT20230371B
  • Ages > 18
  • All Genders

Study Summary

This study was a prospective multicenter cohort of severe pneumonia. And by collecting clinical samples to clarify the correlation between lung microbiome, intestinal microbiome, host susceptibility, and prognosis of severe pneumonia patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. New lung infection that meets one of the following definitions: the patient receivesmechanical ventilation (invasive or non-invasive) due to acute respiratory failure,with a PEEP level of 5cm or above; Patients receiving high flow oxygen therapy witha FiO2 of 50% or more and a PaO2: FiO2 ratio below 300

Exclusion

Exclusion Criteria:

  1. Expected length of stay in ICU is less than 1 day

  2. Pregnant

Study Design

Total Participants: 2000
Treatment Group(s): 2
Primary Treatment: metagenomics
Phase:
Study Start date:
September 25, 2023
Estimated Completion Date:
December 31, 2025

Study Description

The human lung and intestinal microbiota play an important role in human health. At present, the correlation between lung and intestinal microbiota in severe pneumonia patients and host susceptibility is limited to small sample, single center studies. Due to sample size limitations, the pathogenesis of severe pneumonia caused by many pathogens remains unclear. This study plans to construct sputum, alveolar lavage fluid, feces, and whole blood samples of severe pneumonia patients admitted to the ICU from 2023 to 2025, and collect clinical data from patients to identify changes in lung and intestinal microbiome, host susceptibility, and disease progression risk in different groups of patients.

Connect with a study center

  • First Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang 310000
    China

    Active - Recruiting

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang 310000
    China

    Site Not Available

  • Shulan (Hangzhou) hospital

    Hangzhou,
    China

    Active - Recruiting

  • Tongde Hospital of Zhejiang Province

    Hangzhou,
    China

    Active - Recruiting

  • the First People's Hospital of Huzhou

    Huzhou,
    China

    Active - Recruiting

  • The First Hospital of Jiaxing

    Jiaxing,
    China

    Active - Recruiting

  • Pujiang County People's Hospital

    Jinhua,
    China

    Site Not Available

  • Lanxi Hospital of Traditional Chinese Medicine

    Lanxi,
    China

    Active - Recruiting

  • Lishui People's Hospital

    Lishui,
    China

    Active - Recruiting

  • The First People's Hospital of Pinghu

    Pinghu,
    China

    Active - Recruiting

  • Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

    Taizhou,
    China

    Active - Recruiting

  • Wenzhou Central Hospital

    Wenzhou,
    China

    Active - Recruiting

  • Xi'an People's Hospital (Xi'an No.4 Hospital)

    Xi'an,
    China

    Active - Recruiting

  • Henan Provincial People's Hospital

    Zhengzhou,
    China

    Active - Recruiting

  • The Fifth Clinical Medical College of Henan University of Chinese Medicine

    Zhengzhou,
    China

    Active - Recruiting

  • The Second Affiliated Hospital of Zhengzhou University

    Zhengzhou,
    China

    Active - Recruiting

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