Adjunctive Use of Intra-Arterial TNK and Albumin Following Thrombectomy

Inclusion criteria:

1. AIS patients with large vessel occlusion;
2. Age between 18 and 80 years;
3. Baseline NIHSS score ≥ 6; 4 .Successful recanalization after thrombectomy (mTICIgrades ≥ 2b);
4. ASPECTS score ≥ 6 on CT; 6. First episode or previous episode without significantsequelae (mRS ≤ 2); 7. Time from onset to femoral artery puncture ≤ 24 hours; 8. Writteninformed consent provided by the patients or their legal relatives.

Exclusion criteria:

1. Upon admission, the patient's medical history and physical examination revealedmanifestations indicative of congestive heart failure (CHF), such as jugular venousdistention, the presence of a third heart sound, resting tachycardia at a rate of 100beats per minute attributable to heart failure, hepatomegaly, and/or lower extremityedema attributable to heart failure or of unknown etiology;
2. History of acute myocardial infarction within the preceding 3 months;
3. The patient's medical history, electrocardiogram findings upon admission, or physicalexamination indicated the presence of second- or third-degree heart block or anyarrhythmia associated with hemodynamic instability, as determined by theinvestigator's assessment;
4. Acute or chronic renal failure with serum creatinine levels exceeding 2.0 mg/dL;
5. Severe anemia characterized by a hematocrit below 32%;
6. Computed tomography findings upon admission indicating the presence of any form ofhemorrhage;
7. Pregnancy status;
8. Previous history of allergic reactions to albumin administration or TNKadministration;
9. Elevated blood pressure exceeding 185/110 mmHg when investigating the use of albuminadministration or TNK administration;
10. Presence of other potentially life-threatening medical conditions;
11. Individuals with current chronic lung diseases, such as chronic obstructive pulmonarydisease, bronchiectasis, or any other lung disorder that significantly impairs dailyactivities;
12. Individuals with known allergies to albumin or TNK;
13. Patients with reocclusion within 24 hours;
14. Clinical suspicion of aortic coarctation、 bacterial embolism and infectiveendocarditis;
15. Patients with a history of coagulation disorders and systemic bleeding tendencies.