Alternative Treatment Strategies for Stenotrophomonas Maltophilia Pneumonia

Last updated: July 23, 2025
Sponsor: Methodist Health System
Overall Status: Completed

Phase

N/A

Condition

Pneumonia

Treatment

Antibiotic

Clinical Study ID

NCT06112938
034.PHA.2022.A
  • Ages > 18
  • All Genders

Study Summary

Multi center, retrospective chart review of patients admitted to MHS hospitals from April 1, 2017 to March 31, 2022. Patients will be identified through the electronic medical record, and data from those that meet the study inclusion and exclusion criteria will be analyzed. Minimum inhibitory concentration (MIC) data will be interpreted per Clinical & Laboratory Standards Institute (CLSI) standards to determine local patterns of resistance. Multivariable logistic regression will be performed to determine predictors of mortality for S. maltophilia isolates.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • ≥18 years of age

  • S. maltophilia isolated on respiratory or blood culture

Exclusion

Exclusion Criteria:

  • Those that do not meet the inclusion criteria outlined in Section 4.1.

Study Design

Total Participants: 110
Treatment Group(s): 1
Primary Treatment: Antibiotic
Phase:
Study Start date:
July 21, 2022
Estimated Completion Date:
July 14, 2025

Study Description

Stenotrophomonas maltophilia is an aerobic, non-fermenting, Gram-negative bacillus recognized by the World Health Organization as one of the leading multi-drug resistant nosocomial pathogens worldwide. The Investigators aim to examine differences in clinical outcomes and failure rates between standard and alternative treatment strategies such as minocycline (or moxifloxacin, ciprofloxacin, ceftazidime) alone or in combination with TMP-SMX, alternative TMP-SMX dosing regimens, or variations in durations of therapy for the treatment of S. maltophilia infections within Methodist Health System (MHS).

Connect with a study center

  • Methodist Dallas Medical Center

    Dallas, Texas 75201
    United States

    Site Not Available

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