Continuation Study for Latozinemab

Last updated: February 5, 2025
Sponsor: Alector Inc.
Overall Status: Active - Enrolling

Phase

3

Condition

Multiple Sclerosis

Neurologic Disorders

Treatment

Latozinemab

Clinical Study ID

NCT06111014
AL001-CS-302
2023-506805-20-00
  • Ages > 18
  • All Genders

Study Summary

Continuation study to provide continued access to latozinemab for participants who have previously participated in a latozinemab study

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Written informed consent must be obtained and documented (from the participant or,where jurisdictions allow it, from their legal decision maker).

  • Has successfully completed participation in their parent latozinemab study.

  • Female participants must be nonpregnant and nonlactating.

  • Male participants must agree to acceptable contraception use.

Exclusion

Exclusion Criteria:

  • Known history of severe allergic, anaphylactic, or other hypersensitivity reactionsto chimeric, human, or humanized antibodies or fusion proteins.

  • Clinically significant heart disease, liver disease or kidney disease. History orevidence of clinically significant brain disease other than FTD.

Study Design

Total Participants: 35
Treatment Group(s): 1
Primary Treatment: Latozinemab
Phase: 3
Study Start date:
December 08, 2023
Estimated Completion Date:
November 30, 2027

Study Description

This is an open-label continuation study to provide access and assess the safety and tolerability of latozinemab in participants who have completed participation in their parent latozinemab study.

All participants will receive open-label latozinemab at a dose of 60/mg/kg, every 4 weeks (q4w).

Connect with a study center

  • UZ Leuven

    Leuven, 3000
    Belgium

    Site Not Available

  • Parkwood Institute

    London, Ontario N6C 0A7
    Canada

    Site Not Available

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario M4N 3M5
    Canada

    Site Not Available

  • CHU de Bordeaux

    Bordeaux, 33076
    France

    Site Not Available

  • Groupe Hospitalier Pitié Salpétrière

    Paris, 75013
    France

    Site Not Available

  • Universitätsklinikum Ulm - Leimgrubenweg 12-14

    Ulm, 89075
    Germany

    Site Not Available

  • IRCCS - Centro S. Giovanni di Dio Fatebenefratelli

    Brescia, 25125
    Italy

    Site Not Available

  • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico -Via Fracesco Sforza 35

    Milano, 20122
    Italy

    Site Not Available

  • Fondazione IRCCS Di Rilievo Nazionale Istituto Nazionale Neurologico Carlo Besta-VIA MANGIAGALLI 3

    Milano, 20133
    Italy

    Site Not Available

  • Azienda Ospedaliero Universitaria Di Modena Policlinico

    Modena, 41126
    Italy

    Site Not Available

  • Erasmus MC-Dr. Molewaterplein 40

    Rotterdam, 3015 GD
    Netherlands

    Site Not Available

  • Centro Hospitalar E Universitario de Coimbra EPE

    Coimbra, 3000-075
    Portugal

    Site Not Available

  • Centro Hospitalar Universitário Lisboa Norte, EPE - Hospital de Santa Maria

    Lisboa, 1649-028
    Portugal

    Site Not Available

  • Hospital Universitario de Donostia

    Donostia, 20014
    Spain

    Site Not Available

  • Karolinska Universitetssjukhuset Huddinge

    Huddinge, SE-14186
    Sweden

    Site Not Available

  • University College London

    London, WC1NAR
    United Kingdom

    Site Not Available

  • Dignity Health - Arizona

    Phoenix, Arizona 85013
    United States

    Site Not Available

  • John Hopkins University School of Medicine

    Baltimore, Maryland 21205
    United States

    Site Not Available

  • Mayo Comprehensive Cancer Center - PPDS

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Irving Institute for Clinical and Translational Research

    New York, New York 10032
    United States

    Site Not Available

  • University of Cincinnati Gardner Neuroscience Institute

    Cincinnati, Ohio 45219
    United States

    Site Not Available

  • Oregon Health and Science University

    Portland, Oregon 97239
    United States

    Site Not Available

  • University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

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