A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients with Vitiligo

Inclusion Criteria:

• Male and female patients with a confirmed diagnosis of generalized vitiligo withVASI≥3 of the body and VASI on the head and neck ≥0.3 including an F-VASI≥0.1

• Stable or active vitiligo

• Aged 12 or more

• Fitzpatrick skin types III-VI

Exclusion Criteria:

• Fitzpatrick skin types I-II

• Extensive leukotrichia

• Treatment with NB-UVB phototherapy in the last three months prior to study start

• Allergy to afamelanotide or the polymer contained in the implant

• Any other treatment for vitiligo within 30 days prior to the Screening Visit

• History of melanoma or lentigo maligna

• History of dysplastic nevus syndrome

• Any malignant skin lesions

• Presence of severe hepatic disease or hepatic impairment

• Female who is pregnant or lactating

• Female of child-bearing potential not using adequate contraceptive measures

• Sexually active man with a partner of child-bearing potential who is not usingadequate contraceptive measures

• Use of any prior and concomitant therapy which may interfere with the objective ofthe study

• Extensive tattoos