A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 Inhibitor

Inclusion Criteria:

• Have Type 2 Diabetes (T2D)

• Have HbA1c ≥7.0% [53 mmol/mol] to ≤10.5% [91 mmol/mol]

• Have been treated with stable doses of the same formulation of the following for ≥90days prior to screening visit 1 and have maintained the same doses throughrandomization:

• insulin glargine U-100 (100 U/mL) ≥0.25 U/kg/QD (units per kilogram per day) or ≥20 U/QD alone, or

• insulin glargine U-100 (100 U/mL) ≥0.25 U/kg/QD or ≥20 U/QD in combination with

• metformin, or

• SGLT-2 inhibitor, or

• both metformin and SGLT-2 inhibitor.

• Are of stable body weight (±5%) for at least 90 days prior to screening visit 1 andagree to not initiate an intensive diet or exercise program during the study withthe intent of reducing body weight, other than the lifestyle and/or dietary measuresfor diabetes treatment.

• Have a Body Mass Index (BMI) ≥23.0 kg/m^2 at baseline.

Exclusion Criteria:

• Have New York Heart Association functional classification III-IV congestive heartfailure.

• Have had any of the following cardiovascular conditions within 60 days prior tobaseline.

• acute myocardial infarction

• cerebrovascular accident (stroke), or

• hospitalization for congestive heart failure.

• Have acute or chronic hepatitis, including a history of autoimmune hepatitis, signsor symptoms of any other liver disease other than nonalcoholic fatty liver disease

• Have had chronic or acute pancreatitis any time.