The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery

Last updated: February 20, 2024
Sponsor: Taichung Veterans General Hospital
Overall Status: Active - Recruiting

Phase

4

Condition

Hemorrhage

Treatment

Tranexamic acid

Clinical Study ID

NCT06109155
CF23323A
  • Ages > 18
  • All Genders

Study Summary

The goal of this clinical trial is to the dose effect of tranexamic acid and the level of ACT on bleeding in adult cardiac surgery.

The main questions it aims to answer are:

  1. Does higher dose of tranexamic acid reduce the amount of bleeding and blood transfusion?

  2. Does lower ACT level during cardiac surgery reduce the amount of bleeding and blood transfusion?

Participants will divided into four groups which have different tranexamic acid dose and ACT level during cardiac surgery to see if there is any different in the amount of bleeding and blood transfusion.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • adult, cardiac surgery with cardiopulmonary bypass

Exclusion

Exclusion Criteria:

  • pregnant
  • emergency procedure
  • immune compromised
  • aortic surgery
  • end-stage renal disease
  • liver disease
  • critical status
  • incomplete clinical data

Study Design

Total Participants: 150
Treatment Group(s): 1
Primary Treatment: Tranexamic acid
Phase: 4
Study Start date:
February 08, 2024
Estimated Completion Date:
December 31, 2026

Study Description

This study is going to analyze the medical records of patients who underwent cardiac surgery between December 1, 2023, and December 31, 2026.

The investigators will categorize patients into four groups based on anticoagulation indices (ACT 400-600 seconds; ACT > 600 seconds) and tranexamic acid dosages (low dose; high dose) within the range considered safe for CPB.

The primary outcome will be the volume of postoperative bleeding within 24 hours for each group.

The findings of this study will contribute to the existing clinical evidence and provide insights for the monitoring and pharmacological management in cardiac surgery.

Connect with a study center

  • Taichung Veterans General Hospital

    Taichung, 40705
    Taiwan

    Active - Recruiting

  • Taichung Veterans General hospital

    Taichung, 40705
    Taiwan

    Active - Recruiting

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