BGT007H Cells for the Treatment of Refractory Digestive System Tumors

Inclusion Criteria:

1. Voluntarily sign a written informed consent;
2. Age ≥18 years old, ≤70 years old, male and female;
3. Expected survival ≥ 3 months;
4. The Eastern Cancer Collaboration (ECOG) physical fitness score was 0-1;
5. Biopsy specimen or pathological wax section test (within 3 years before the signing ofinformed consent) : Target protein test is positive;
6. At least one measurable lesion according to RECIST v1.1 solid tumor evaluationcriteria;
7. Patients with recurrent/metastatic refractory digestive tract tumors (esophageal,gastric, pancreatic, or colorectal cancer) who have previously received second-line orabove standard treatment failure or intolerance;
8. It is possible to establish a vein access for simple or intravenous blood collection,and there are no other contraindications for blood cell separation;
9. having adequate organ and bone marrow function, as defined below: Blood routineexamination Neutrophil count (NEU #) ≥1.0×10^9/L Platelet count (PLT) ≥80×10^9/LHemoglobin concentration ≥90g/L Liver function: subjects without liver metastasesAspartate aminotransferase (AST) ≤2.5× Upper Limit of Normal (ULN) Alanineaminotransferase (ALT) ≤2.5× Upper Limit of Normal (ULN) Total bilirubin (TBIL) ≤1.5×ULN Liver function: Subjects with liver metastases Aspartate aminotransferase (AST) ≤5× Upper limit of normal (ULN) Alanine aminotransferase (ALT) ≤5× Upper limitof normal (ULN) Liver function: Subjects with liver metastases or Gilbert syndromeTotal bilirubin (TBIL) ≤2×ULN renal function Creatinine clearance (CCR) ≥50 mL/minCoagulation function International Standardized ratio (INR) ≤1.5×ULN Activated partialthromboplastin time (APTT) ≤1.5×ULN
10. Toxic side effects left over from previous anti-tumor therapy (radiotherapy,chemotherapy, targeted therapy, etc.) ≤ grade 1 (CTCAE 5.0);
11. During the study period and for 6 months after the end of dosing, fertile subjects (both male and female) must use effective medical contraception. For female subjectsof reproductive age, a pregnancy test should be performed within 72 hours before thefirst dose and the result is negative.

Exclusion Criteria:

1. Active central nervous system metastases (except those stable after treatment);
2. HIV positive, HBsAg positive, HBV DNA copy number positive (quantitative detection ≥1000cps/ml), HCV antibody positive and HCV RNA positive;
3. Patients with mental or mental illness who cannot cooperate with treatment andefficacy evaluation;
4. Subjects with severe autoimmune diseases and long-term use of immunosuppressants;
5. Active or uncontrolled infections requiring systemic treatment during the 14 daysprior to enrollment;
6. Any unstable systemic disease (including but not limited to) : Active infections (except local infections); unstable angina pectoris; cerebralischemia or cerebrovascular accident (within 6 months prior to screening); myocardialinfarction (within 6 months before screening); Congestive heart failure (New YorkHeart Association [NYHA] classification ≥III); Severe arrhythmias requiring medicaltreatment; have a heart condition that requires treatment or uncontrolled hypertensionafter treatment (blood pressure > 160mmHg/100 mmHg);
7. dysfunction of important organs such as lung, brain and kidney;
8. The subject has undergone major surgery or severe trauma within 4 weeks prior toreceiving cell therapy, or is expected to undergo major surgery during the studyperiod;
9. Received any systemic chemotherapy, immunotherapy, or small molecule targeted therapywithin 1-2 weeks prior to anapheresis or within 5 half-lives, whichever is shorter;
10. The subject currently has or has had other malignant tumors that cannot be curedwithin 3 years, except cervical carcinoma in situ or basal cell carcinoma of the skin,and other malignant tumors with disease-free survival of more than 5 years;
11. Received chimeric antigen receptor modified T cells (including CAR-T, TCR-T) withinsix months;
12. Graft-versus-host disease (GVHD);
13. Participants who were receiving systemic steroid therapy prior to screening and whowere determined by the investigator to require long-term use of systemic steroidtherapy during treatment (except for inhalation or topical use); And subjects treatedwith systemic steroids within 72 h prior to cell transfusion (except for inhalation ortopical use);
14. Severe allergies or history of allergies;
15. Subjects requiring anticoagulation therapy;
16. Pregnant or breastfeeding women, or have a pregnancy plan within six months (for bothmen and women)
17. Researchers believe that there are other reasons for not being included in thetreatment.