Evaluate Performance and Safety of Hyalo4 Skin in Acute and Chronic Wounds

Inclusion Criteria:

1. Signed written informed consent.
2. Male or female ≥18 years.
3. Patients selected to be treated with Hyalo4 Skin Gel.
4. Patients with wound of the following etiology: first and second degree burns; surgicalwounds; vascular ulcers; metabolic ulcers; pressure ulcers.
5. Patients followed on an outpatient or home basis.
6. Wound area ≥ 10 cm2 and ≤ 100 cm2

Exclusion Criteria:

1. Patients < 18 years.
2. Patients with acute or chronic infected lesions.
3. Hospitalized patients.
4. Women who are pregnant or breastfeeding or women who could become pregnant and are notusing effective contraception.
5. Patients with acute or chronic lesions at high risk of infection, presenting at leastone of the following criteria:

• Stalled wound, without any clinical sign of healing progression
• Immune system disorders
• Protein-energy malnutrition
• Alcohol, smoking and drug abuse (50ml of spirit, 0,5L of wine and 10cigarettes/day)
• Conditions associated with hypoxia and/or poor tissue perfusion
• Corticosteroid, cytotoxic or immunosuppressive therapy.

6. Subjects unable to understand informed consent or having a high probability ofnon-compliance with the study procedures and or non-completion of the study accordingto investigator's judgement