Oxygen Extraction-guided Transfusion

Last updated: September 19, 2024
Sponsor: Università degli Studi di Ferrara
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Individualized red blood cell transfusion strategy

European guidelines red blood cell transfusion strategy

Clinical Study ID

NCT06102590
OXYTRIP
  • Ages > 18
  • All Genders

Study Summary

In critically ill patients, optimized strategies for red blood cells transfusion (RBCT) are still controversial. Most recent guidelines suggest that clinical practice in ICU setting should follow a restrictive approach to RBCT (i.e., hemoglonim level < 7.0 g/dL).In our previous study, oxygen extraction ratio (O2ER) has shown good performance as a marker to identify the correct timing for RBCT, potentially affecting 90-day mortality in non-bleeding, critically ill patients [11]. Moreover, our data suggested that an individualized strategy for RBCT may reduce the incidence of acute kidney injury (AKI), which is possibly related to a better delivery of oxygen and organ perfusion.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Hb levels ≤ 9.0 g/dL (as confirmed through a blood test and/or through blood gasanalysis)

  • Presence of an arterial line and a central venous line (either jugular orsubclavian), with confirmed correct position of the catheter tip at the atrio-cavaljunction (allowing correct estimation of central venous saturation, ScvO2).

Exclusion

Exclusion Criteria:

  • Age < 18 years;

  • Pregnancy

  • Clinical evidence of acute bleeding

  • Diagnosis of haematological malignancy

  • Diagnosis of sickle cell disease, or other diseases exposing the patient to chronicRCBTs

  • Acquired or congenital disorders of coagulation

  • Patients with ongoing AKI of stage 1 or worse and/or known chronic kidney disease (CKD) of stage G3a or worse, defined as glomerular filtration rate below 60 for aminimum of 3 months

Study Design

Total Participants: 324
Treatment Group(s): 2
Primary Treatment: Individualized red blood cell transfusion strategy
Phase:
Study Start date:
November 04, 2023
Estimated Completion Date:
February 01, 2026

Connect with a study center

  • Hospital Erasme

    Bruxelles,
    Belgium

    Site Not Available

  • Università di Ferrara

    Ferrara, 44121
    Italy

    Active - Recruiting

  • Anestesia e Rianimazione Cardio-Toraco-Vascolare

    Siena,
    Italy

    Active - Recruiting

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