Cold Snare Polypectomy Versus Hot Snare Polypectomy for Resection of Small Pedunculated Colorectal Polyps:a Randomized Controlled Trial

Last updated: December 15, 2024
Sponsor: Ningbo No. 1 Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hemorrhage

Polyps

Treatment

hot snare polypectomy

cold snare polypectomy

Clinical Study ID

NCT06097650
2023-140A-YJ01
  • Ages 18-75
  • All Genders

Study Summary

Endoscopic resection of pedunculated polyps mainly focuses on how to prevent bleeding, and also needs to pay attention to the convenience of resection and the integrity of resection, which means that different endoscopic resection strategies should be adopted for pedunculated polyps with different pedicle sizes. Small pedunculated polyps with heads smaller than 20mm and pedicles smaller than 5mm are defined as having a relatively small risk of bleeding. Preliminary studies in recent years suggest that the use of cold snare polypectomy for small pedunculated polyps may also be a safe resection strategy. However, for small pedunculated polyps, ASGE and ESGE guidelines currently recommend hot snare polypectomy in the middle and lower pedicles (evidence level medium). Therefore, the provision of high-quality clinical evidence related to cold resection techniques in the resection strategy of small pedunculated polyps may provide a basis for revision of guidelines.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients undergoing endoscopic resection of small and medium pedicled polyps inthe First Affiliated Hospital of Ningbo University from October 2023 to August 2026; 2. Age 18-75 years old; 3. Patients who voluntarily agreed to participatein this study and signed informed consent.

Exclusion

Exclusion Criteria:

  1. Persons under 18 years of age 2. Persons unwilling or unable to provideinformed consent 3. Treatment or radiotherapy for malignant diseases, severechronic heart or lung diseases, coronary or cerebrovascular events requiringhospitalization within the last 3 months 4.Malignant polyps have infiltratedthe pedicle 5. Abdominal symptoms such as severe abdominal pain, abdominaldistension, and nausea 6.Patients with inadequate intestinal preparation 7.Patients with lifelong anticoagulant therapy or severe bleeding diseases,patients who have recently taken anticoagulant drugs or antiplatelet drugs (within 1 week) 8.Pregnant or lactating

Study Design

Total Participants: 196
Treatment Group(s): 2
Primary Treatment: hot snare polypectomy
Phase:
Study Start date:
October 18, 2023
Estimated Completion Date:
August 31, 2026

Connect with a study center

  • Ningbo first hospital

    Ningbo, Zhejiang 315000
    China

    Active - Recruiting

  • the First Affiliated Hospital of Ningbo University

    Ningbo, Zhejiang 315000
    China

    Active - Recruiting

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