dTMS for Subjective Cognitive Decline

Inclusion Criteria:

• have a family history of late onset sporadic Alzheimer's disease (AD) as defined byhaving a first degree relative, living or deceased, with a probable or confirmeddiagnosis of AD

• have subjective memory decline and concern about memory changes

• score 26 or higher on the Montreal Cognitive Assessment (MoCA)

• are willing to provide informed consent

• are able to follow the treatment schedule

• are stable on medications for 2 months and are not expected to change medicationduring the entire study period (if they are taking medications)

• have a satisfactory safety screening questionnaire for TMS

• have an informant/study partner who is able to complete study questionnairesregarding the participant

Exclusion Criteria:

• have a metal plate in their head, except in the mouth (such as an ear implant,implanted brain stimulators, aneurysm clips)

• have known increased pressure or a history of increased pressure in their brain,which may increase their risk for having seizures

• have a cardiac pacemaker

• have an implanted medication pump

• have a central venous line

• have a significant heart condition

• have current depression or a history of any psychotic disorder, bipolar disorder,eating disorder, obsessive compulsive disorder, post-traumatic stress disorder, ordementia other than AD

• have a history of substance abuse in the last 6 months

• have a history of stroke or other brain lesions

• have a personal history of epilepsy

• have a family history of epilepsy

• are a pregnant or breast-feeding woman

• have a history of abnormal MRI of the brain

• have significant hearing loss requiring use of hearing aids

• have untreated hypo- or hyper-thyroidism

• have TMS contraindications

• have unstable medical condition(s)

• regularly use benzodiazepines or other hypnotics within 2 weeks of randomization