RFA or Chemical Neurolysis of the Genicular Nerves Compared to Conservative Treatment for Knee Pain Caused by OA

Inclusion Criteria:

1. Adult patients of both sexes, >35 years who are not a candidate for TKA due to youngage, old age, comorbidity or technical reasons.
2. OKS < 30 on a scale from 0 (severe function) to 48 points (satisfactory function).
3. Continued pain in the target knee that is moderate to severe (defined as NRS ≥ 6 on an 11-point NRS scale) either constantly or with motion despite at least 3 months ofconservative treatments. Conservative treatment can include: active physiotherapy,pharmacological treatment of pain (acetaminophen or NSAIDs) and intra-articularcorticosteroid infiltration.
4. Radiologic confirmation of arthritis for the target knee. Defined as the KellgrenLawrence (KL) score of 2 or more on X-ray or MRI.

Exclusion Criteria:

1. Patient with prior ablation of the genicular nerves, prior partial, resurfacing, orTKA of the target knee (residual hardware).
2. Patient with a history of neurovascular injury or recent trauma of the lowerextremities.
3. Patient with chronic widespread pain.
4. Polyneuropathy and/or radicular pain in the lower extremities.
5. Patient is currently implanted with a neurostimulator.
6. Local or systemic infection (bacteraemia).
7. Uncontrolled immune suppression.
8. Intra-articular injections (steroids, hyaluronic acid, platelet enriched plasma, stemcell, …) in the target knee within 90 days from randomisation.
9. Arthroscopic debridement/lavage into the target knee within 180 days fromrandomisation.
10. BMI<18,5 kg/m2 and patients with minimal subcutaneous tissue thickness that would notaccommodate ablation with phenol or radio frequency (risk of skin burns).
11. Allergies to products used during the procedure (lidocaine, phenol, contrast dye).
12. Patients who have a planned TKA in the near future, defined as patients who alreadyhave agreed on a date for the TKA procedure.
13. Patients with psychosocial problems as determined by the investigator.